Results 51 to 60 of about 5,252,361 (312)

Predicting Drug-Target Interactions Using Drug-Drug Interactions

PLoS ONE, 2013
Computational methods for predicting drug-target interactions have become important in drug research because they can help to reduce the time, cost, and failure rates for developing new drugs. Recently, with the accumulation of drug-related data sets related to drug side effects and pharmacological data, it has became possible to predict potential drug-
Kim, Shinhyuk, Jin, Daeyong, Lee, Hyunju
openaire   +5 more sources

Global Overview of Drug Demand and Supply: Latest Trends, Cross-cutting Issues [PDF]

, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core  

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Reliability of the GAIN-SS, CRAFTT and PESQ screening instruments for substance use among South African adolescents

South African Journal of Psychiatry, 2016
Introduction: Screening for adolescent substance use can assist with the early identification of substance-related problems and guide the provision of appropriate services. As such, psychometrically sound screening tools are needed. The aim of this study
Tara Carney, Bronwyn Myers, Johann Louw
doaj   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Abnormal proliferation of gut mycobiota contributes to the aggravation of Type 2 diabetes

Communications Biology, 2023
β-glucan from Candida albicans promotes high-fat diet induced insulin resistance and related metabolic disorders in mice and C. albicans is enriched in type 2 diabetes (T2D) patients, supporting a role of gut mycobiota in the progress of T2D.
Li Bao, Ying Zhang, Guoying Zhang, Dechun Jiang, Dan Yan   +4 more
doaj   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

The Young Women’s Health CoOp in Cape Town, South Africa: Study protocol for a cluster-randomised trial for adolescent women at risk for HIV

BMC Public Health, 2018
Background South Africa remains the global epicentre of HIV infection, and adolescent women have the highest incidence of HIV in the country. South Africa also has high rates of alcohol and other drug (AOD) use, violence, and gender inequality.
Wendee M. Wechsberg, Felicia A. Browne, Tara Carney, Bronwyn Myers, Alexandra Minnis, Robert MacDonald, Jacqueline W. Ndirangu, Leslie B. Turner, Brittni N. Howard, Nathaniel Rodman   +9 more
doaj   +1 more source

Study protocol of the Our Futures Vaping Trial: a cluster randomised controlled trial of a school-based eHealth intervention to prevent e-cigarette use among adolescents

BMC Public Health, 2023
Background Effective and scalable prevention approaches are urgently needed to address the rapidly increasing rates of e-cigarette use among adolescents.
Lauren A. Gardner, Amy-Leigh Rowe, Emily Stockings, Katrina E. Champion, Leanne Hides, Nyanda McBride, Steve Allsop, Siobhan O’Dean, Matthew Sunderland, Yong Yi Lee, Cathy Mihalopoulos, Becky Freeman, Janni Leung, Hayden McRobbie, Lexine Stapinski, Nicole Lee, Louise Thornton, Jennifer Debenham, Maree Teesson, Nicola C. Newton   +19 more
doaj   +1 more source

Characteristics of drug users who do or do not have care of their children

, 2004
Aims - To compare the relative frequency of eight indicators of problem drug use and potentially adverse social circumstances in drug using parents and non-parents and to explore whether a profile based on these characteristics differs according to ...
Advisory Council on the Misuse of Drugs, Barnard, Bauman, Bays, Donmall, Famularo, Gawin, Hogan, Jeremy, Johnson, Johnson, Kandel, Kaplan-Sanoff, Kelley, Kolar, Pilowsky, Rubin, Suchman, Wilens   +18 more
core   +1 more source