Results 81 to 90 of about 839,545 (360)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Drug Policy and the HIV Pandemic in Russia and Ukraine [PDF]
, 2004 Over the past three years Russia and Ukraine have experienced one of the fastest growing HIV pandemics in Europe. In contrast to other parts of the world, the main driver behind the rate of infection is injecting drug use. Recent government policies have
Klein, Axel +2 more
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Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Alcohol consumption in Colombian university students
Universidad y Salud, 2017 Introduction: Alcohol consumption is conceived as a public health problem. Given the significant prevalence of consumption and its negative consequences, it is necessary to contribute to the prevention from the identification of populations at risk, such
Sonia Betancourth Zambrano +2 more
doaj +1 more source
The impact of worker values on client outcomes within a drug treatment service [PDF]
, 2008 Background: Little attention has been paid to understanding the impact of values, attributes and characteristics of drugs workers on therapeutic relationships and treatment outcomes.
Bourne, RHL, Phillips, R
core +2 more sources
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
THE CORRELATION BETWEEN POOR ORAL HYGIENE AND ORAL HEALTH-RELATED QUALITY OF LIFE AMONG DRUG USERS
Jurnal Berkala EpidemiologiBackground: The quality of life among drug users has become an increasingly important public health issue. One of the factors suspected to contribute to this is poor oral hygiene, which may result from reduced saliva production due to long-term use of ...
Riky Hamdani +2 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Tipping the Balance: Why Legal Services Are Essential to Health Care for Drug Users in Ukraine [PDF]
, 2008 Examines the need to integrate legal support for drug users with harm reduction programs to effectively stem the spread of HIV/AIDS. Discusses approaches, legal problems, and recommendations for government policy and for nongovernmental ...
Carey, Corinne, Tolopilo, Andrey
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