Results 111 to 120 of about 3,569,315 (302)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Avaliação da qualidade do uso de medicamentos em idosos

Revista de Saúde Pública
OBJETIVO: Avaliar a qualidade do uso de medicamentos através da análise do padrão do uso, do grau de concordância com listas de medicamentos essenciais, do valor terapêutico e das interações medicamentosas encontradas entre mulheres com mais de 60 anos ...
Gabriela B G Mosegui, Suely Rozenfeld, Renato Peixoto Veras, Cid M M Vianna   +3 more
doaj  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Drug Utilization Review Program Newsletter Drug Utilization Review Bulletin

, 2010
In 2009 this publication's title changed from Drug Utilization Review Bulletin to Drug Utilization Review Newsletter This internet resource contains several newsletters issued throughout several ...
Kansas. Department of Health and Environment
core   +1 more source

Watch-Antibiotic: Teicoplanin: Usage Practices in Various Departments of a Tertiary Care Hospital, Coimbatore, Western Tamil Nadu

National Board of Examinations Journal of Medical Sciences
Background: Watch - antibiotics have high potential to develop resistance. Teicoplanin is one of the antibiotics given under Watch classification in Access, Watch and Reserve (AWaRe), 2023 classification.
M S Umamageswari, G R Gayathri, S Jeevithan, T P Kalaniti, A Vijaya Kumar, M Mohanapriya, B Bharath Kumar, T M Karthikeyan, S Bhuvaneshwari, A T Sathiya Vinotha   +9 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

A (des)informação sobre medicamentos: o duplo padrão de conduta das empresas farmacêuticas

Cadernos de Saúde Pública
Diferentes fatores foram identificados como exercendo influência sobre o comportamento dos prescritores de medicamentos. Estudos realizados enfatizam o lugar proeminente ocupado pelas fontes de informação disponíveis para os médicos, muitos deles ...
José Augusto C. Barros
doaj  

Trends of antiseizure medication utilization among pregnant people in four Canadian provinces from 1998 to 2023; a study from the Canadian mother-child cohort active surveillance initiative (CAMCCO)

Frontiers in Pharmacology
BackgroundEpilepsy management during pregnancy is crucial for both the mother and fetus. The use of antiseizure medications (ASMs) during pregnancy requires careful consideration due to their potential effects on maternal and fetal health.MethodsThis ...
Payam Peymani, Anick Berard, Anick Berard, Brandace Winquist, Padma Kaul, Padma Kaul, Odile Sheehy, Alekhya Lavu, Christine Leong, Christine Leong, Jamie Falk, Joseph A. Delaney, Joseph A. Delaney, Kaarina Kowalec, Kaarina Kowalec, Marcus Ng, Chelsea Ruth, Chelsea Ruth, Laila Aboulatta, Silvia Alessi-Severini, Silvia Alessi-Severini, Roxana Dragan, Shelley Derksen, Olesya Barrett, Golnaz Shams, Sherif Eltonsy, Sherif Eltonsy   +26 more
doaj   +1 more source

The impact of Medicare Part D on Medicare-Medicaid Dual-eligible Beneficiaries' Prescription Utilization and Expenditures [PDF]

Features of Part D gave rise to broad concern that the drug benefit would negatively impact prescription utilization among the six million dual eligible beneficiaries, either during the transition from state Medicaid to Part D coverage, or in the long ...
G. Caleb Alexander, Wesley Yin, Anirban Basu   +2 more
core