Results 101 to 110 of about 703,096 (358)
Frontiers in PharmacologyIntroductionWith an increasing prevalence, dementia is one of the most disabling diseases among the elderly. Impaired cognitive function and behavioral and psychological symptoms predispose patients to medication non-adherence, resulting in increased ...
Eduardo Gutiérrez-Abejón +9 more
doaj +1 more source
Improving the Medicare Part D Program for the Most Vulnerable Beneficiaries [PDF]
, 2007 Discusses some of the obstacles patients experience using Medicare Part D and makes specific recommendations to strengthen the program, such as using simpler, more standard procedures and ensuring that needed counseling support is ...
Jeanne Finberg +2 more
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Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction [PDF]
, 2011 BACKGROUND: Burkholderia cenocepacia is a threatening nosocomial epidemic pathogen in patients with cystic fibrosis (CF) or a compromised immune system. Its high level of antibiotic resistance is an increasing concern in treatments against its infection.
Fang, K. +9 more
core +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Clinical and Translational ScienceMonoclonal antibodies (mAbs) are critical components in the therapeutic landscape, but their dosing strategies often evolve post‐approval as new data emerge.
Nai Lee +6 more
doaj +1 more source
Study of the Impact of the ACA Implementation in Kentucky: Semi-Annual Report [PDF]
, 2015 This report was produced by the State Health Access Data Assistance Center (SHADAC) at the University of Minnesota as part of a mixed-methods study, Study of the Impact of the Affordable Care Act (ACA) Implementation in Kentucky, funded by the Foundation
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Mediterranean Journal of Pharmacy and Pharmaceutical SciencesDrug utilization in Neonatal Intensive Care Units is complex due to the immaturity of neonates and the critical nature of their ailments. Understanding prescribing patterns is essential for promoting rational pharmacotherapy and improving neonatal ...
Mufida A. Yamane
doaj +1 more source
Cost-Sharing: Effects on Spending and Outcomes [PDF]
, 2010 Reviews what is known and not known about the effects of consumer cost-sharing on distribution of and total spending, health outcomes, services, and prescription drugs and how responses to cost-sharing vary by socioeconomic factors and health ...
Katherine Swartz
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source