Results 81 to 90 of about 3,569,315 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A Study of Psychotropic Drugs Being Prescribed to the Patients Attending the Psychiatric Outpatient Department in a Tertiary Care Hospital

علوم بهداشتی ایران, 2020
BACKGROUND & PURPOSE: Drug utilization research evaluates the appropriateness of the prescriptions which is important in clinical practice. Psychotropic polypharmacy is a major problem in psychiatric practice, which can lead to the development of adverse
Adit Atul Deshmukh, Sangeeta Sanjay Dabhade, Balasaheb Baburao Ghongane   +2 more
doaj  

Ethics in drug utilization research

This chapter focuses on research ethics, an area where norms and values are universally accepted. These norms and values are expressed in codes of ethics, that is, a set of principles and guidelines regarding ethics.
Wettermark, Björn, Druedahl, Louise C., Sporrong, Sofia Kälvemark, Trečiokienė, Indrė, Kälvemark Sporrong, Sofia,, Druedahl, Louise C.,, Trečiokienė, Indrė,, Wettermark, Björn,   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Real‐World Utilization of Medications With Pharmacogenetic Recommendations in Older Adults: A Scoping Review

Clinical and Translational Science
Pharmacogenetic testing provides patient genotype information which could influence medication selection and dosing for optimal patient care. Insurance coverage for pharmacogenetic testing varies widely.
Bella D. Ianni, Chin Hang Yiu, Edwin C. K. Tan, Christine Y. Lu   +3 more
doaj   +1 more source

Antimicrobial Consumption and Resistance Dynamics Across Healthcare Level: Global Evidence and Stewardship Implications

Pathogens
Background/Objectives: Antimicrobial resistance (AMR) is a critical global public health challenge driven by inappropriate and excessive antimicrobial use (AMU) across human, animal, and environmental sectors.
Neha Raut, Anis A. Chaudhary, Harshad Patil, Supriya Shidhaye, Ruchi Khobragade, Milind Umekar, Mohamed A. M. Ali, Rashmi Trivedi   +7 more
doaj   +1 more source

Determinants and Policy Implications of Drug Utilization in the Philippines [PDF]

The drug question has emerged recently, which is the crux of the Philippine health concerns today. While studies on the supply side of pharmaceuticals have been profuse, the demand side seems to be neglected.
Bautista, Cristina
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source