Results 81 to 90 of about 2,933,736 (305)

Evaluation of the Peer Support Program (Student Drug Prevention) 1986-1987

, 2019
The Peer Support program is a school based program funded by the National Campaign Against Drug Abuse (NCADA) as a drug prevention strategy. Prior to the existence of the NCADA the program was funded through the NSW Drug and Alcohol Authority.
Directorate of the Drug Offensive
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Multilevel analyses in drug utilization research

Multilevel regression analysis (MLRA) is a statistical technique that is suitable for the study of correlated outcomes within multilevel organisational and other data structures.
Merlo, Juan,, Leckie, George,, Lund University.   +2 more
core   +1 more source

Non-adherence to antidementia medications and associated factors: a study of Spanish population-based registry data

Frontiers in Pharmacology
IntroductionWith an increasing prevalence, dementia is one of the most disabling diseases among the elderly. Impaired cognitive function and behavioral and psychological symptoms predispose patients to medication non-adherence, resulting in increased ...
Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, Eduardo Gutiérrez-Abejón, M. Aránzazu Pedrosa-Naudín, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Isabel Díaz Planelles, F. Javier Álvarez, F. Javier Álvarez   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Drug utilization research in the area of cancer drugs

, 2016
Increased biological understanding of cancer diseases has resulted in a paradigm shift in the medical treatment of cancer. Despite encouraging advances, most cancer types are still incurable and cancer is the second most common cause of death in ...
Wilking, Ulla,, Jönsson, Bengt,, Wilking, Nils,, Lund University., Hofmarcher, Thomas,   +4 more
core  

The Glasgow Declaration A call for improvement of the availability and accessibility of drug utilization data

Drug utilization research (DUR) intends to support health authorities in the development of evidence-informed pharmaceutical policy and practice guidelines, with the interest of the patients and communities in mind.
Gvozdanović, K, Taxis, K, Petrović, AT, Vogler, S, Ivanovska, V, Hoffmann, M, Almarsdottir, AB, Pont, L, Bennie, M, Mueller, T, Blix, HS, Trečiokienė, I, Iaru, I, Sanfélix-Gimeno, G, Wettermark, B, MacBride-Stewart, S, Elseviers, M, Benkő, R, Selke, GW, Poluzzi, E   +19 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source