Results 71 to 80 of about 3,569,315 (302)

Proton pump inhibitor prescribing at hospital discharge: a real-world analysis from two Italian internal medicine units

Italian Journal of Medicine
Dear Editor, Proton pump inhibitors are highly effective for acid-related disorders and for gastrointestinal protection in selected high-risk patients...
Paola Gnerre, Marco Pellecchio, Andrea Ceccardi, Elisa Schiavetta, Martina Penso, Alberto Gandolfo, Lara Rebella, Alessandra Brescia, Amatore Morando, Martina Bagnasco, Alessandro Cavaliere, Monica Cirone, Bruna Rebagliati, Elena Farulla, Michele Orlando   +14 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Shifts Toward Direct Oral Anticoagulants in Ambulatory Care: Utilization Trends and SARIMA Forecasts

Pharmacoepidemiology
Background: Anticoagulant treatment is central to the prevention and management of thromboembolic cardiovascular disease, and contemporary practice has increasingly shifted toward direct oral anticoagulants.
Vasiliki Gougoula, Konstantinos Kassandros, Panagiotis Nikolaos Lalagkas, Evangelia Nena, Georgia Kaiafa, Vangelis G. Manolopoulos, Maria Panagopoulou, Theodoros C. Konstantinides, Christos Kontogiorgis   +8 more
doaj   +1 more source

Use of corticosteroids for remission induction therapy in patients with new-onset ulcerative colitis in real-world settings

Journal of Market Access & Health Policy, 2019
Background: Corticosteroids may be temporarily effective for ulcerative colitis (UC), but long-term use increases the risk of adverse drug reactions.
Motohiro Okayasu, Haruhiko Ogata, Yuji Yoshiyama   +2 more
doaj   +1 more source

Qualitative methods in drug utilization research

The value of qualitative methods in drug utilization research is plentiful, and the possible contexts to study range from politics/policy, health care settings, and staff to the general population and individual patients.
Druedahl, Louise C., Sporrong, Sofia Kälvemark, Kälvemark Sporrong, Sofia,, Druedahl, Louise C.,   +3 more
core   +1 more source

Physician perceptions of drug utilization management.

, 2022
Physician perceptions of drug utilization management.
Marie Louise Edwards (13833882), Noam Kirson (10179012), Perry T. Yin (1336239), Scott Howell (13833888), Keith Bratti (13833885), Michael Kuehn (2434828), Anupam B. Jena (6852560)   +6 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Do Drug Plans Matter? Effects of Drug Plan Eligibility on Drug Use Among the Elderly, Social Assistance Recipients and the General Population [PDF]

The 1984 Canada Health Act does not require that the provinces subsidize prescription drugs. Many provinces do, however, provide categorical coverage to the elderly, social assistance recipients and others, although the generosity of coverage is highly ...
Paul V. Grootendorst, Mitchell Levine
core   +2 more sources