Results 91 to 100 of about 3,569,315 (302)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The Glasgow Declaration A call for improvement of the availability and accessibility of drug utilization data

Drug utilization research (DUR) intends to support health authorities in the development of evidence-informed pharmaceutical policy and practice guidelines, with the interest of the patients and communities in mind.
Gvozdanović, K, Taxis, K, Petrović, AT, Vogler, S, Ivanovska, V, Hoffmann, M, Almarsdottir, AB, Pont, L, Bennie, M, Mueller, T, Blix, HS, Trečiokienė, I, Iaru, I, Sanfélix-Gimeno, G, Wettermark, B, MacBride-Stewart, S, Elseviers, M, Benkő, R, Selke, GW, Poluzzi, E   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Drug Use Pattern and Antenatal Care Utilization among Pregnant Women in the First Trimester: A Cross-Sectional Study in a Tertiary Care Hospital in Eastern India

Amrita Journal of Medicine
Background: Medication use during pregnancy requires caution due to altered pharmacokinetics and possible teratogenic effects. Early antenatal care (ANC) offers a vital opportunity for rational prescribing and preventing unsafe self-medication.
Sk. Sabir Rahaman, Avisekh Mazumdar, Nasim Akhtar, Sarmi Naskar, Ranit Bag, Mahananda Mondal, Sampurna Roy   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Other title: Kansas Medicaid Drug Utilization Review Board; Other title: Drug Utilization Review Board

, 2015
application/pdf; "February 16, 2015."; Presentation before the Kansas Legislature, Senate Public Health and Welfare, presented by Kelley Melton, Senior Pharmacy Program Manager, Division of Health Care Finance, Kansas Department of Health and Environment.
Melton, Kelley, Pharm.D.
core  

Multilevel analyses in drug utilization research

Multilevel regression analysis (MLRA) is a statistical technique that is suitable for the study of correlated outcomes within multilevel organisational and other data structures.
Merlo, Juan,, Leckie, George,, Lund University., Merlo, Juan, Leckie, George   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source