Results 111 to 120 of about 412,569 (303)

New Cassane Diterpenoids from Caesalpinia sappan and their Antiplasmodial Activity

Molecules, 2017
One new cassane diterpene possessing an unusual N bridge between C-19 and C-20 named caesalsappanin R (1), as well as another new diterpene caesalsappanin S (2), were isolated from the seeds of Caesalpinia sappanwith methanol extract.
Nai-Liang Zhu, Zhong-Hao Sun, Mei-Geng Hu, Tong-Yu Wu, Jing-Quan Yuan, Hai-Feng Wu, Yu Tian, Peng-Fei Li, Jun-Shan Yang, Guo-Xu Ma, Xu-Dong Xu   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Evaluation of Knowledge, Attitude, and Practice about Rational Prescribing and Use of Drugs among General Practitioners in Tehran City, Iran

مجله دانشکده پزشکی اصفهان, 2018
Background: Accuracy and expertise are the essential factors that must be applied by general practitioners (GPs) due to their important role in preventing irrational prescribing.
Bita Shahrami, Maliheh Shahbalaei, Ali Hamzeh-Zadeh, Mansoor Rastegarpanah   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Retrospective review of medicine utilization for noncommunicable diseases in three public sector pharmacies in Jamaica

Revista Panamericana de Salud Pública
Objective. The rational use of medicines offers a cost-saving strategy to maximize therapeutic outcomes for developing and developed countries. The aim of this study was to evaluate the rational use of medicines for selected noncommunicable diseases ...
Donna-Marie Wynter-Adams, Peta-Gaye Thomas-Brown, Lisa Bromfield, Marcia Williams, Janice Bunting-Clarke   +4 more
doaj   +1 more source

Homelessness and Public Health in Los Angeles [PDF]

, 2020
Los Angeles faces a housing crisis of unprecedented scale. After years of underinvestment, in 2016/2017 LA County voters approved Measures H and HHH, which provided an infusion of resources for homeless services, permanent housing, and integrated ...
Clair, Kimberly, Kuhn, Randall, Richards, Jessica, Roth, Sarah   +3 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of a Medication Decision Support System on Albumin Prescribing: A Pre-post Study in Intensive Care Units of Imam Reza Hospital, Mashhad, Iran

Journal of Research in Pharmacy Practice
Objective: Medication Decision Support Systems (MDSS) are increasingly integrated into hospital information systems to reduce prescribing errors and enhance evidence-based clinical decision-making.
Naghme Dashti, Hesamoddin Hosseinjani, Saeid Eslami, Seyed Mohammad Tabatabaei, Hasan Vakili Arki   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Prescription patterns and drug utilization in respiratory tract infections: implications for antimicrobial stewardship at a tertiary care teaching hospital

Monaldi Archives for Chest Disease
Respiratory tract infections (RTIs) are common causes of hospital admissions and are often treated with multiple medications, including antibiotics, contributing to antimicrobial resistance.
Princy Domnic Dsouza, Sai Phalguna Prakash Chitralu, Chandrashekhar Mallikarjun Patil, Vinod Ashok Koujalagi, Sanatkumar Bharamu Nyamagoud   +4 more
doaj   +1 more source