Results 131 to 140 of about 16,766,351 (298)

Human Albumin Utilization in Patients Admitted to a University-affiliated Hospital in Iran

Journal of Pharmacoeconomics and Pharmaceutical Management, 2018
Background: As an essential human protein and an expensive biological drug, albumin is, in several cases, prescribed without an appropriate indication. This study determined the compatibility of albumin administration with the current standard protocols
Afshin Gharekhani, Hamid Noshad, Soheil Teimouri, Haleh Rezaee, Abasad Gharedaghi, Sepideh Rahigh-Aghsan   +5 more
doaj  

Artificial intelligence for drug delivery: Yesterday, today and tomorrow

Acta Pharmaceutica Sinica B
The global pharmaceutical drug delivery market is forecasted to grow to USD 2546.0 billion by 2029. The expanding pharmaceutical market urgently needs a more efficient drug research and development paradigm.
Yiyang Wu, Nannan Wang, Ping Xiong, Ruifeng Wang, Jiayin Deng, Defang Ouyang   +5 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Ethics in drug utilization research

This chapter focuses on research ethics, an area where norms and values are universally accepted. These norms and values are expressed in codes of ethics, that is, a set of principles and guidelines regarding ethics.
Wettermark, Björn, Druedahl, Louise C., Sporrong, Sofia Kälvemark, Trečiokienė, Indrė, Kälvemark Sporrong, Sofia,, Druedahl, Louise C.,, Trečiokienė, Indrė,, Wettermark, Björn,   +7 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The Importance and Use of Drug Utilization Review and Pharmacoeconomics [PDF]

Value in Health, 2014
Yue, X., Zhao, C.
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Effect of providing drug utilization review information on tricyclic antidepressant prescription in the elderly. [PDF]

J Med Syst, 2018
Park MJ, Kim MH, Shin SM, Chung SY.
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source