Results 141 to 150 of about 16,766,351 (298)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Drug Utilization Review of Cholinesterase Inhibitors in Quebec [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2008
Fadi, Massoud, Marc, Dorais, Claudie, Charbonneau, Bénédicte, Lescrauwaet, Jean-Marc, Boucher, Jacques, LeLorier   +5 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Granulocyte Colony-Stimulating Factor Use in a Large Iranian Hospital: Comparison with American Society of Clinical Oncology (ASCO) Clinical Practice Guideline

International Journal of Hematology-Oncology and Stem Cell Research, 2016
Background: Granulocyte Colony Stimulating factors (GCSF) are high cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia.
Sarah Mousavi, Mina Dadpoor, Farzaneh Ashrafi   +2 more
doaj  

Evaluation of preventable adverse drug reactions by implementation of the nationwide network of prospective drug utilization review program in Korea. [PDF]

PLoS One, 2018
Lee J, Noh Y, Lee S.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

"Brown bag" simulations to teach drug utilization review. [PDF]

Am J Pharm Educ, 2014
Castillo S, Begley K, Hoie E, Elsasser G, Augustine S.   +4 more
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

The Glasgow Declaration A call for improvement of the availability and accessibility of drug utilization data

Drug utilization research (DUR) intends to support health authorities in the development of evidence-informed pharmaceutical policy and practice guidelines, with the interest of the patients and communities in mind.
Gvozdanović, K, Taxis, K, Petrović, AT, Vogler, S, Ivanovska, V, Hoffmann, M, Almarsdottir, AB, Pont, L, Bennie, M, Mueller, T, Blix, HS, Trečiokienė, I, Iaru, I, Sanfélix-Gimeno, G, Wettermark, B, MacBride-Stewart, S, Elseviers, M, Benkő, R, Selke, GW, Poluzzi, E   +19 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source