Results 61 to 70 of about 82,737 (314)

Icaritin Ameliorates Cisplatin‐Induced Mitochondrial Metabolic Dysfunction‐Associated Nephrotoxicity and Synergistically Potentiates Its Antitumor Efficacy

Advanced Science, EarlyView.
In this study, scRNA‐seq and chemoproteomics are integrated to characterize CDDP‐bound proteins at single‐cell resolution in tumor‐bearing mice. Additionally, the research demonstrates that ICA alleviates CDDP‐induced nephrotoxicity while enhancing its chemotherapeutic efficacy.
Piao Luo, Junhui Chen, Yehai An, Kun Meng, Wei Zhou, Wenhui Li, Jing Liu, Wentong Zhao, Weiyi He, Ting Cao, Jingnan Huang, Sha Feng, Shiguang Yang, Hongling Hu, Jiaxian Liao, Hengkai He, Mingjing Hao, Qian Zhang, Jigang Wang, Yue Gao   +19 more
wiley   +1 more source

Current status of herbal and their future perspectives [PDF]

, 2007
Traditional medicine is the synthesis of therapeutic experience of generations of practicing physicians of indigenous systems of medicine. Throughout the history of mankind, many infectious diseases have been treated with herbals.
Ponnampalam Gopalakrishnakone, Ramar Perumal R. Samy   +1 more
core   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Danshen: A Popular Chinese Cardiac Herbal Drug

Journal of the American College of Cardiology, 2006
The recently published document in JACC on complementary and integrative medicine ([1][1]) left out one very important herbal drug, danshen. Because it is believed to have properties of improving microcirculation, increasing coronary blood flow, suppressing thromboxane formation, inhibiting ...
openaire   +1 more source

Systematic review on safety and drug interaction of herbal therapy in hyperlipidemia: a guide for internist. [PDF]

, 2015
Because of reporting high side effects related to biosynthetic drugs, recent attention has been paid to the use of herbs instead of chemical drugs to balance serum lipids. The present systematic review aimed to evaluate the safety of herbal medicines and
Ahmadi, S., Gharipour, M., Mohammadizadeh, F., Rafieian-Kopaei, M., Rouhi-Boroujeni, H., Rouhi-Boroujeni, H.   +5 more
core  

Long-Term Effects of Traditional Chinese Medicine and Hypnotherapy in Patients with Severe Endometriosis - a Retrospective Evaluation [PDF]

, 2010
Background: 15% of patients with severe endometriosis suffer from pain symptoms in spite of pharmacological and surgical treatments. In this retrospective study we aimed to assess the effectiveness of a combined therapy of Traditional Chinese medicine ...
Böhling, Barbara, Meissner, Karin, Schweizer-Arau, Annemaria   +2 more
core   +1 more source

Aloe‐Emodin Targeting FOXC2 Disrupts NETs Formation and EMT‐Driven Postoperative Peritoneal Adhesion Through TGF‐β1‐Smad2/3 Pathway

Advanced Science, EarlyView.
Forkhead box protein C2 (FOXC2) is highlighted as a pivotal effector in postoperative peritoneal adhesion (PPA) formation. Mechanically, FOXC2 mediates NETs‐induced EMT alterations through the TGF‐β1‐Smad2/3 pathway. Aloe‐emodin (AE) ameliorates FOXC2‐driven fibrosis by blocking NETs formation and EMT changes through this pathway.
Lili Yang, Yunda Fang, Yuheng Lian, Ziyang Kong, Jia Miao, Yanqi Chen, Wen Li, Feiyan Chen, Bin Zhang, Yao Chen, Yaoyao Bian   +10 more
wiley   +1 more source

Herbal hepatotoxicity in traditional and modern medicine: Actual key issues and new encouraging steps

Frontiers in Pharmacology, 2015
Plants are natural producers of chemical substances, providing potential treatment of human ailments since ancient times. Some herbal chemicals in medicinal plants of traditional and modern medicine carry the risk of herb induced liver injury (HILI) with
Rolf eTeschke, Alex eEickhoff
doaj   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Cox-2 gene overexpression in ureteral stump urothelial carcinoma following nephrectomy for renal cell carcinoma: a case report

Journal of Medical Case Reports, 2012
Introduction A primary ureteral stump tumor after a nephrectomy is rare; urothelial carcinoma of the ureteral stump after a nephrectomy for renal cell carcinoma is even rarer.
Chang Wei-Pin, Chien Tsu-Ming, Wang Yu-Shiuan, Chiu Siou-Jin, Lee Mei-Hui, Chang Wei-Chiao, Chou Yii-Her, Hou Ming-Feng   +7 more
doaj   +1 more source