Results 171 to 180 of about 81,901 (217)

In Silico to In Cerebro—Development of the Orexin Receptor Antagonist “Photorexant” for Photomodulation In Vitro and in Mouse Brains

Angewandte Chemie International Edition, EarlyView.
Following a structure‐based design approach, photoswitchable derivatives of the FDA‐approved drug suvorexant were designed, docked, synthesized, and characterized pharmacologically at the orexin 1 and 2 receptors (OX1R and OX2R). Optimized “photorexant” showed up to an 11‐fold difference in IC50 between photoisomers, enabled dynamic and reversible ...
Marcus Angermann, Marie H. Deventer, Vicente Ledesma‐Martin, Nuno Martinho, Alix Flake, Silvia Mori, Angel Nuñez, Jaime Pignatelli, Rita C. Guedes, Christophe P. Stove, Michael Decker   +10 more
wiley   +1 more source

Research Needs in Philippine Pharmaceutical Sciences: A Qualitative Perspective from Regulatory and Clinical Research Sectors of the Pharmaceutical Industry. [PDF]

Acta Med Philipp
Peña IG, Alos HC, Calara NKR, Pavia HGC, Bulatao BPI.   +4 more
europepmc   +1 more source

Neuroanatomical diversity in Teleocichla with new volumetric and histological insights into the encephalon of Teleocichla monogramma Kullander 1988

The Anatomical Record, EarlyView.
Abstract Teleocichla comprises small cichlids that inhabit the rapid streams of Amazonian rivers; however, there has been limited research on their encephalon morphology. This study examined the neuroanatomy of four species, focusing on volumetric measurements of their encephalon subregions, and providing a histological description of the encephalon of
Renan Leão‐Reis, Keila Xavier Magalhães, Thiago Nilton A. Pereira, Janice Muriel‐Cunha, Alberto Akama   +4 more
wiley   +1 more source

Assessment of IPAY 2027 Medicare drug price negotiation maximum fair prices with prices in most-favored nation reference countries. [PDF]

J Manag Care Spec Pharm
Gabriel N, Martin K, Cousin EM, Li KH, Grueger J, Sullivan SD.   +5 more
europepmc   +1 more source

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source

Accelerating Generic Long-Acting Antiretrovirals for Global HIV Treatment: Workshop Findings and a Roadmap to Access. [PDF]

Clin Pharmacol Ther
Arshad U, Gaayeb L, Pertinez H, Rajoli RKR, Watkins M, Nimbolkar P, Perazzolo S, Pagi B, Wensing A, Khoo S, Boffito M, Holm R, Panos Z, Mahaka I, Venter F, Kottiri B, Crawford KW, Ho RJY, Clayden P, Domanico P, Struble K, Owen A, Flexner C.   +22 more
europepmc   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source

Multifaceted and educational interventions to improve prescribing indicators in the Middle East and North Africa Region: a systematic review and meta-analysis. [PDF]

Int J Clin Pharm
Ilyas M, Chivese T, Hadi MA, Ncube NBQ, Khan MN.   +4 more
europepmc   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

The use of generic versus brand names in (clinical) pharmacology education across Europe: a cross-sectional survey. [PDF]

Eur J Clin Pharmacol
Slezáková V, Rychlíčková J, Cazaubon Y, Donker EM, van Leeuwen E, Likic R, Mazánková D, Piët JD, De Ponti F, Raasch W, van Rosse F, Sanz EJ, Schwaninger M, van Agtmael MA, Tichelaar J.   +14 more
europepmc   +1 more source