Results 251 to 260 of about 4,484,991 (333)

Optimization of the Use of Generic Medications in Oncology: Improving Safety and Therapeutic Quality. [PDF]

J Clin Med
Gómez Abreo D, Alarcón Cano DF, Ayala F, Belalcázar Carvajal N, Berrouet Mejía MC, Beltrán O, Calderón-Ospina CA, Castro-Salguero H, Escobar Cárdenas DM, Lema-Medina M, Marín Zuluaga JI, Milla Bernabé P, Niño Velasco RE, Osorio Estévez R, Ortiz JM, Rojas-Melo LJ, Urrego M, Vargas C, Zuluaga AF.   +18 more
europepmc   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Recent changes in discretionary denials of drug patent challenges. [PDF]

Health Aff Sch
Tu SS, Rai A, Kesselheim AS.
europepmc   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths

Annals of Neurology, EarlyView.
Objective Though it is widely known that tau deposition affects brain structure, the precise localization of these effects is poorly understood, especially in relation to gyral and sulcal anatomy. We investigated whether tau pathology in Alzheimer's disease (AD) preferentially affects sulci, and particularly sulcal depths.
Samira A. Maboudian, Corrina S. Fonseca, Adam C. Martersteck, Yishu Chao, Yuheng Chen, Daniela Ushizima, Duygu Tosun, Lea T. Grinberg, Kevin S. Weiner, William J. Jagust, for the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Economic implications of the different statin prescribing patterns in Central Portugal: a longitudinal analysis. [PDF]

J Pharm Policy Pract
Abrantes C, Negrão LG, Coelho C, Castel-Branco MM, Figueiredo IV, Fernandez-Llimos F.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Bioequivalence Study of Bedaquiline and Sirturo^® in Healthy Chinese Subjects Under Fasting and Postprandial Conditions: A Randomized, Open-Label, Single-Dose, Crossover Trial. [PDF]

Drugs R D
Li Y, Wu Y, Cai S, Huang X, Ye L, Wang L, Zhang Y, Wang Y, Tao X.   +8 more
europepmc   +1 more source

Phytoplankton Tune Local pH to Actively Modulate Circadian Gravitactic Behavior

Advanced Physics Research, EarlyView.
Diel vertical migration hides an unexpected twist: Phytoplankton quietly engineer their local pH landscape, splitting into behaviorally distinct sub‐groups which stay separated even in identical conditions. Circadian pH changes, occuring over the course of a day, reshape their gravitactic behavior and physiological functions in ways scientists have ...
Arkajyoti Ghoshal, Soumitree Mishra, Jayabrata Dhar, Hans‐Peter Grossart, Anupam Sengupta   +4 more
wiley   +1 more source

Do medicine prices reflect therapeutic value? Evidence from a comparison of the United Arab Emirates and Australia. [PDF]

Cost Eff Resour Alloc
Ashraf A, Sim R, Ong SC.
europepmc   +1 more source

Neuroanatomical diversity in Teleocichla with new volumetric and histological insights into the encephalon of Teleocichla monogramma Kullander 1988

The Anatomical Record, EarlyView.
Abstract Teleocichla comprises small cichlids that inhabit the rapid streams of Amazonian rivers; however, there has been limited research on their encephalon morphology. This study examined the neuroanatomy of four species, focusing on volumetric measurements of their encephalon subregions, and providing a histological description of the encephalon of
Renan Leão‐Reis, Keila Xavier Magalhães, Thiago Nilton A. Pereira, Janice Muriel‐Cunha, Alberto Akama   +4 more
wiley   +1 more source