Results 31 to 40 of about 4,484,991 (333)
Generic versus brand-name drugs used in cardiovascular diseases [PDF]
, 2016 This meta-analysis aimed to compare the efficacy and adverse events, either serious or mild/moderate, of all generic versus brand-name cardiovascular medicines.
Boccia, Stefania +9 more
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Mechanistic modeling of generic orally inhaled drug products: A workshop summary report
CPT: Pharmacometrics & Systems Pharmacology, 2023 In silico mechanistic modeling approaches have been designed by various stakeholders with the goal of supporting development and approval of generic orally inhaled drug products in the United States.
Ross L. Walenga +12 more
doaj +1 more source
The implications of WTO accession on the pharmaceutical industry in China [PDF]
, 2002 Given the limited capabilities of R&D and global distribution channels, and the virtual non-existence of patented drugs, the Chinese pharmaceutical industry has little chance to enter the global market of Western prescription drugs and compete with the ...
Yeung, Godfrey
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The economic impact of the transition from branded to generic oncology drugs.
Current Oncology, 2019 Background Economic evaluations are an integral component of many clinical trials. Costs used in those analyses are based on the prices of branded drugs when they first enter the market. The effect of genericization on the cost-effectiveness (ce) or cost-
W. Cheung +12 more
semanticscholar +1 more source
CPT: Pharmacometrics & Systems Pharmacology, 2022 Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and trial design or ...
Nikunjkumar Patel +14 more
doaj +1 more source
Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity
Asian Journal of Pharmaceutical Sciences, 2022 Amphotericin B (AmB) is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections. Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer ...
Yuri Svirkin +13 more
doaj +1 more source
RNAi drugs: Next generation drugs? [PDF]
Chinese Science Bulletin, 2020 Gene therapy aims to apply biotechnological techniques to correct a defective gene through administrating therapeutic nucleic acids or editing a defective gene. The approaches used in gene therapy include traditional transgene, genome editing, such as CRISPR/CAS9, RNA interference (RNAi) and antisense oligonucleotides (ASOs), etc.
Bingxue Yan +5 more
openaire +1 more source
Mechanistic modeling of drug products applied to the skin: A workshop summary report
CPT: Pharmacometrics & Systems Pharmacology, 2023 The development of a generic drug product involves demonstrating that there is no significant difference in the rate and extent to which the active ingredient becomes available at the site of action, relative to the reference listed drug product.
Eleftheria Tsakalozou +9 more
doaj +1 more source
Generic antiepileptic drugs—Safe or harmful in patients with epilepsy?
Epilepsia, 2018 Generic antiepileptic drugs (AED) are significantly cheaper than brand name drugs, and may reduce overall health care expenditures. Regulatory bodies in Europe and North America require bioequivalence between generic and innovator drugs with regard to ...
M. Holtkamp, W. Theodore
semanticscholar +1 more source
EClinicalMedicine, 2021 Background: Over the past decade, U.S. FDA has approved 10 opioid analgesics in abuse-deterrent formulations (ADFs). ADFs are intended to reduce abuse of a prescription opioid through manipulation of the product to use one or more routes of abuse ...
Liang Zhao +10 more
doaj +1 more source