Results 141 to 150 of about 6,254,499 (310)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Salt production and iodization practices among artisanal salt producers in selected districts within the Greater Accra and Central Regions of Ghana

Heliyon
Background: This study was conducted to assess salt production and iodization practices by artisanal salt producers located at six districts across Greater Accra and Central regions.
Benjamin Osei Tutu, Bella Rosaling Nkansah, Nana Akua Serwaa Yeboah, Faustina Atupra, Roderick Kwabena Daddey-Adjei, Delese A.A. Darko   +5 more
doaj   +1 more source

Renal amyloidosis in intravenous drug users [PDF]

, 2006
John O. Connolly, Julian D. Gillmore, Helen J. Lachmann, Andrew Davenport, Philip N. Hawkins, Robin G. Woolfson   +5 more
openalex   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

In Vitro Model for Simulating Drug Delivery during Balloon-Occluded Transarterial Chemoembolization [PDF]

, 2021
Jorge Aramburu, Raúl Antón, Junichi Fukamizu, Daiki Nozawa, Makoto Takahashi, Kouji Ozaki, Juan Carlos Ramos, Bruno Sangro, José Ignacio Bilbao, Kosuke Tomita, Tomohiro Matsumoto, Terumitsu Hasebe   +11 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A co-assembly platform engaging macrophage scavenger receptor A for lysosome-targeting protein degradation

Nature Communications
Targeted degradation of proteins has emerged as a powerful method for modulating protein homeostasis. Identification of suitable degraders is essential for achieving effective protein degradation.
Qian Wang, Xingyue Yang, Ruixin Yuan, Ao Shen, Pushu Wang, Haoting Li, Jun Zhang, Chao Tian, Zhujun Jiang, Wenzhe Li, Suwei Dong   +10 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Points to consider: efficacy and safety evaluations in the clinical development of ultra-orphan drugs [PDF]

, 2017
Kojiro Maeda, Masayuki Kaneko, Mamoru Narukawa, Teruyo Arato   +3 more
openalex   +1 more source

Prediction of drug side effects with transductive matrix co-completion [PDF]

, 2023
Xujun Liang, Ying Fu, Lingzhi Qu, Pengfei Zhang, Yongheng Chen   +4 more
openalex   +1 more source