Results 211 to 220 of about 6,254,499 (310)

Hollow silica capsules for amphiphilic transport and sustained delivery of antibiotic and anticancer drugs

, 2018
Isabel Gessner, Eva Krakor, Anna Jurewicz, Veronika Wulff, Lasse Kling, Silke Christiansen, Nicolas Brodusch, Raynald Gauvin, Laura Wortmann, Martina Wolke, Georg Plum, Astrid Schauß, John Krautwurst, Uwe Ruschewitz, Shaista Ilyas, Sanjay Mathur   +15 more
openalex   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effects of Modifying Supportive Care Medications in Combination Therapy with Pertuzumab, Trastuzumab, and Taxane Anticancer Drugs. [PDF]

Pharmacy (Basel)
Takagi M, Maeda S, Maeda M, Fujio Y, Hirobe S.   +4 more
europepmc   +1 more source

Polyesters and polyestercarbonates for controlled drug delivery. Part I. Tailoring of the drug release

, 2013
Katarzyna Jelonek, Janusz Kasperczyk
openalex   +2 more sources

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Impact of antipsychotics, antiparkinsonian drugs, and anthraquinone stimulant laxatives on severe constipation in patients with schizophrenia. [PDF]

PCN Rep
Nadaya T, Inaguma T, Nagao T, Ishida T.
europepmc   +1 more source

Solubility Enhancement of Lipophilic Drugs-Solid Self Micro-Emulsifying Drug Delivery System

, 2016
Pratiksha Sonawale, Amol Patil, Asmit Kamble, Mangesh A. Bhutkar   +3 more
openalex   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Why is schizophrenia a huge graveyard of molecules? [PDF]

Schizophrenia (Heidelb)
Parellada E, Gassó P.
europepmc   +1 more source

Cis‐unsaturated sphingolipids support growth of sphingoid base‐deficient yeast but impair plasma membrane integrity

FEBS Open Bio, EarlyView.
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi, Saki Sugihara, Yohei Ishibashi, Kono Yushi, Hazuki Yamauchi, Motohiro Tani   +5 more
wiley   +1 more source