Results 231 to 240 of about 6,850,919 (315)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Automated and personalized glioblastoma tumor organoid drug screening platform exposes sensitivity to proteasome and HDAC inhibitors. [PDF]

NPJ Precis Oncol
Jungwirth G, Paul A, Wöllner A, Warta R, Cao J, Fermi V, Jassowicz L, Dao Trong P, von Deimling A, Debus J, Krieg S, Unterberg A, Abdollahi A, Herold-Mende C.   +13 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Interpol review of forensic toxicology, 2023-2025. [PDF]

Forensic Sci Int Synerg
Ip SC, Chan CW, Chan CW, Chu A, Chung WW, Hui JW, Ku KW, Lee WS, Lo KM, Poon KC, Wong WC, Cheung BK, Cheng JY.   +12 more
europepmc   +1 more source

Rapid drug susceptibility testing of Mycobacterium tuberculosis against first-line drugs simultaneously all-in-one plate by using a novel high-sensitive reporter phage combined with the BACTEC MGIT 960 system. [PDF]

Infect Dis Poverty
Ma R, Zhang Y, Zhu M, Zhang M, Qian C, Wu J, Hu Z, Guo M, Fan XY.   +8 more
europepmc   +1 more source

The role of albumin-globulin ratio in peripheral arterial disease among hypertensive adults: evidence from a large-scale multicenter study. [PDF]

Front Endocrinol (Lausanne)
Yu C, Yang Y, Liao X, Wu L.
europepmc   +1 more source

Nanoparticle Drug Delivery Systems: The Future Direction for the Treatment of Tumors. [PDF]

Int J Nanomedicine
Zhao Y, Nie X, Yan H, Ren J, Zhao J, Tong L, Zhao L, Zhang G, Liu H.   +8 more
europepmc   +1 more source

Identification of efflux inhibitors through a drug repurposing strategy in <i>Candida albicans</i>. [PDF]

Front Cell Infect Microbiol
Marques D, Costa SS, Rodrigues L.
europepmc   +1 more source