Results 241 to 250 of about 3,598,260 (304)

Bacterial Carriage and Invasive Infections Among People Who Inject Drugs: Clinical and Molecular Epidemiology in an Australian Prospective Cohort. [PDF]

Open Forum Infect Dis
Attwood LO, O'Keefe D, Wisniewski JA, Doan NQ, Petrovic B, Beiers M, Vujovic O, Curtis SJ, Higgs P, Hawkey J, Doyle JS, Peel TN, Peleg AY, Dietze P, Stewardson AJ.   +14 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Social Media Discussions of Anti-Diabetic Drugs and the Popularity of GLP-1 Therapies: Content Analysis. [PDF]

JMIR Diabetes
Stallion C, Khan T, Guerrero C, Tsipas S, Wozniak G.   +4 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

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Drug-Drug Interactions: Antiretroviral Drugs and Recreational Drugs

Recent Patents on CNS Drug Discovery, 2015
With the advances in antiretroviral (ARV) therapy, patients with Human Immunodeficiency Virus (HIV) infection are living longer, however, some patients encounter co- morbidities which sometimes require treatment. Therefore, during the treatment with ARV drugs these patients could take several recreational drugs (e.g.
Orietta, Staltari, Christian, Leporini, Benedetto, Caroleo, Emilio, Russo, Antonio, Siniscalchi, Giovambattista, De Sarro, Luca, Gallelli   +6 more
openaire   +2 more sources

Therapeutic Drug Monitoring and Drug–Drug Interactions Involving Antiretroviral Drugs

Antiviral Therapy, 2005
The consensus of current international guidelines for the treatment of HIV infection is that data on therapeutic drug monitoring (TDM) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) provide a framework for the implementation of TDM in certain defined scenarios in clinical practice.
Boffito, M, Acosta, E, Burger, D, Fletcher, C, Flexner, C, Garaffo, R, Gatti, G, Kurowski, M, PERNO, CARLO FEDERICO, Peytavin, G, Regazzi, M, Back, D.   +11 more
openaire   +4 more sources