Results 241 to 250 of about 6,254,499 (310)

Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium

FEBS Open Bio, EarlyView.
By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita, Toyonobu Usuki, Robert R. Kay, Tamao Saito   +3 more
wiley   +1 more source

AΙ-Driven Drug Repurposing: Applications and Challenges. [PDF]

Medicines (Basel)
Keramida P, Syrigos NK, Kouvela M, Poulakou G, Charpidou A, Fiste O.   +5 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Prescription Patterns of Antiseizure Medication in Adult Patients with Epilepsy in Kazakhstan (2021-2023). [PDF]

Med Sci (Basel)
Kalinina D, Aimyshev T, Muxunov A, Utebekov Z, Kyrgyzbay G, Kimadiev D, Zhumabaeva G, Gaipov A, Sarria-Santamera A.   +8 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Cost of treatment of metastatic non-small lung cancer in Sweden, 2011-2023. [PDF]

Acta Oncol
Kim K, Sweeting M, Wilking N, Jönsson LM.   +3 more
europepmc   +1 more source

Mining Real-World Big Data to Characterize Adverse Drug Reaction Quantitatively: Mixed Methods Study [PDF]

Qi-Xuan Yue, Ruofan Ding, Wei-Hao Chen, Lvying Wu, Ke Liu, Zhi‐Liang Ji   +5 more
openalex   +1 more source

Cloning, expression, purification, and structural modeling of the Chandipura virus matrix protein

FEBS Open Bio, EarlyView.
This research protocol offers a guide for the cloning, expression, and purification of the Chandipura virus matrix protein using E. coli. It also includes a step‐by‐step procedure for cloning, expressing, and conducting fluorescence imaging of GFP‐fused Chandipura virus matrix protein in mammalian cell lines.
Mariana Grieben
wiley   +1 more source

Children's drug research and development incentives and market pricing optimization based on medical imaging. [PDF]

Sci Rep
Mu X, Wu L.
europepmc   +1 more source

A device for the drug-capsule administration into the rat stomach and its pharmacological application

, 1981
Shuichi Takeda, Takeshi Abe, Masamichi OTSUKA   +2 more
openalex   +2 more sources