Results 261 to 270 of about 3,396,597 (298)

"I think that that really could benefit a lonely user:" perceptions of overdose response hotlines among people who use opioids. [PDF]

Harm Reduct J
Gicquelais RE, Chenoweth RP, Jacobson N, Conway C, Bryan GM.   +4 more
europepmc   +1 more source

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

DNA-protein cross-links emerge as major contributors to chemotherapeutic cytotoxicity at physiological equitoxic doses. [PDF]

Sci Rep
Shoulkamy MI, Mohammed TO, Ide H, Nakano T.   +3 more
europepmc   +1 more source

Drug-induced interstitial lung disease: a pharmacovigilance study of twelve immunomodulatory and antineoplastic agents. [PDF]

J Pharm Health Care Sci
Yayan J, Rasche K.
europepmc   +1 more source

Advanced QSPR modeling of profens using machine learning and molecular descriptors for NSAID analysis. [PDF]

Sci Rep
Ahmed WE, Hanif MF, Siddiqui MK, Gegbe B.   +3 more
europepmc   +1 more source

Development and optimization of an injectable in-situ gel system for sustained release of anti-tuberculosis drugs. [PDF]

Sci Rep
Balu P, Srikanth S, Gnandhas DP, Durai RD, Ulaganathan V, B Narayanan VH.   +5 more
europepmc   +1 more source

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Drug-Drug Interactions: Antiretroviral Drugs and Recreational Drugs

Recent Patents on CNS Drug Discovery, 2015
With the advances in antiretroviral (ARV) therapy, patients with Human Immunodeficiency Virus (HIV) infection are living longer, however, some patients encounter co- morbidities which sometimes require treatment. Therefore, during the treatment with ARV drugs these patients could take several recreational drugs (e.g.
Antonio Siniscalchi, Benedetto Caroleo, Luca Gallelli, Orietta Staltari, Emilio Russo, Christian Leporini, Giovambattista De Sarro   +6 more
openaire   +3 more sources

Therapeutic Drug Monitoring and Drug–Drug Interactions Involving Antiretroviral Drugs

Antiviral Therapy, 2005
The consensus of current international guidelines for the treatment of HIV infection is that data on therapeutic drug monitoring (TDM) of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) provide a framework for the implementation of TDM in certain defined scenarios in clinical practice. However, the utility of TDM
Boffito, M, Acosta, E, Burger, D, Fletcher, C, Flexner, C, Garaffo, R, Gatti, G, Kurowski, M, PERNO, CARLO FEDERICO, Peytavin, G, Regazzi, M, Back, D.   +11 more
openaire   +5 more sources