Results 101 to 110 of about 228,450 (313)
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Status of drugs and substance abuse among Secondary School students in Kenya
, 2019 oai:ojs.ajada.nacada.go.ke:article/1Early initiation of substance use increases the risk of future substance use disorders and other negative outcomes. This study conducted between March and June 2016 explored the secondary students’ drugs and substance ...
Muteti, John, Kamenderi, Morris
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[The physician, the drug abuser and drug abuse].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990 Drug abusers have a low tolerance for unpleasant and painful emotions and experience a need for chemical relief through use of narcotics, tranquilizers and analgesics. Physicians may show a tendency to comply with their request for such drugs, partly because they give way under pressure (threats, violence) and partly because of their own unconscious ...
openaire +1 more source
Advanced Science, EarlyView.ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang +15 more
wiley +1 more source
Amuc_1473 Links Gut Microbes to Skeletal Homeostasis and Counteracts Multifactorial Osteoporosis
Advanced Science, EarlyView.Amuc_1473, a previously uncharacterized protein enriched in Akkermansia muciniphila‐derived extracellular vesicles, is identified as a gut–bone messenger that promotes osteogenesis and inhibits osteoclastogenesis by engaging transcriptional and translational regulators in bone cells.
Shan‐Shan Rao +28 more
wiley +1 more source
A case-control study on alcohol and psychiatric disorders as risk factors for drug abuse pattern
Cadernos de Saúde PúblicaWe evaluated alcohol and psychiatric disorders as risk factors for the pattern of drug abuse/dependence in a matched case-control study (370 adults).
Claudia S. Lopes, Rosely Sichieri
doaj +2 more sources
The Effects of Alcohol Regulation on Physical Child Abuse [PDF]
The purpose of this paper is to examine the effects of alcohol regulation on physical child abuse. Given the established relationship between alcohol consumption and violence, the principal hypothesis to be tested is that an increase in the price of ...
Sara Markowitz, Michael Grossman
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Advanced Science, EarlyView.TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang +12 more
wiley +1 more source
Alcohol and other drug treatment services in Australia 2013–14 [PDF]
, 2015 Alcohol and other drug treatment services across Australia provide a broad range of treatment services and support to people using drugs and to their families and friends. This report presents the information for 2013–14 about publicly funded alcohol and
Australian Institute of Health and Welfare
core
Advanced Science, EarlyView.The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu +10 more
wiley +1 more source