Results 81 to 90 of about 228,450 (313)
Advanced Science, EarlyView.Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang +13 more
wiley +1 more source
Harms and benefits associated with psychoactive drugs: findings of an international survey of active drug users. [PDF]
, 2013 There have been several recent efforts in the UK and the Netherlands to describe the harms of psychoactive substances based on ratings of either experts or drug users.
Noronha, LA +4 more
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Pharmacology of amphetamine-type designer drugs [PDF]
, 2013 In this thesis project, we studied the pharmacology of long-known psychostimulants and of novel amphetamine-type designer drugs in vitro. On the basis of the pharmacological characterization, we focused on the drug effects in humans, investigating the ...
Simmler, Linda
core +1 more source
Advanced Science, EarlyView.By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao +11 more
wiley +1 more source
روانشناسی بالینی و شخصیت, 2009 The present research investigates the relationship between family factors and the students' attitude towards drugs. 863 (male and female) secondary school students were selected through randomized cluster sampling. They responded to the "Attitude towards
A. Delawar, A.M. Rezayi, A. Alizadeh
doaj
Substance abuse and women: a comprehensive qualitative analysis of the literature
, 1999 Plan BIn this comprehensive meta-analytic research study, substance abuse as it pertains to women is discussed in detail. A brief history of substance use and women will be presented plus a brief history of pharmacology research and its relevance to ...
Gignac, Susan
core
Advanced Science, EarlyView.SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang +17 more
wiley +1 more source
Socioeconomic Disparities and Self-reported Substance Abuse-related Problems [PDF]
Addiction and Health, 2018 Background: It is not well understood whether the self-reported experience of substance abuse-related problems differs by socioeconomic status.Methods: We conducted a secondary analysis using the 2013 National Survey on Drug Use and Health (NSDUH) on ...
Kesha Baptiste-Roberts, Mian Hossain
doaj
The Ethics of “Smart Drugs”: Moral Judgments About Healthy People's Use of Cognitive-Enhancing Drugs
, 2012 What moral concerns are relevant when judging the use of cognitive-enhancing (CE) drugs by healthy people? University students evaluated competitive fairness, distributive fairness, peer pressure, naturalness, and dosage form.
core +1 more source
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source