Results 91 to 100 of about 31,224 (320)

DRUSEN CHARACTERIZATION WITH MULTIMODAL IMAGING [PDF]

Retina, 2010
To characterize the known appearance of cuticular drusen, subretinal drusenoid deposits (reticular pseudodrusen), and soft drusen as revealed by multimodal fundus imaging and to create an explanatory model that accounts for these observations.Reported color, fluorescein angiographic, autofluorescence, and spectral domain optical coherence tomography ...
Christine A. Curcio, Richard F. Spaide
openaire   +3 more sources

Activated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD‐Like Pathology in Mice

Aging Cell, EarlyView.
Our study reveals that overactivation of both mTOR complexes through mLST8 in RPE cells triggers AMD‐like pathology and cellular dysfunction. This finding highlights the critical role of balanced mTOR signaling in retinal health and suggests that targeting both complexes could be therapeutic for AMD treatment.
Olivia Chowdhury, Sridhar Bammidi, Pooja Gautam, Vishnu Suresh Babu, Haitao Liu, Peng Shang, Ying Xin, Emma Mahally, Mihir Nemani, Victoria Koontz, Kira Lathrop, Katarzyna M. Kedziora, Jonathan Franks, Ming Sun, Joshua W. Smith, Lauren R. DeVine, Robert N. Cole, Nadezda Stepicheva, Anastasia Strizhakova, Sreya Chattopadhyay, Stacey Hose, Jacob Samuel Zigler Jr., José‐Alain Sahel, Jiang Qian, Prasun Guha, James T. Handa, Sayan Ghosh, Debasish Sinha   +27 more
wiley   +1 more source

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu   +13 more
wiley   +1 more source

ACHIKO-D350: A dataset for early AMD detection and drusen segmentation [PDF]

, 2014
Age related macular degeneration is the third leading cause of global blindness. Its prevalence is increasing in these years for the coming of ”aging population”. Early detection and grading can prevent it from becoming severe and protect vision.
Laude, Augustinus, Lim, Tock Ham, Liu, Huiying, Liu, Jiang, Wong, Damon W.K., Xu, Yanwu   +5 more
core   +2 more sources

Normative prospective data on automatically quantified retinal morphology correlated to retinal function in healthy ageing eyes by two microperimetry devices

Acta Ophthalmologica, EarlyView.
Abstract Purpose The relationship between retinal morphology, as assessed by optical coherence tomography (OCT), and retinal function in microperimetry (MP) has not been well studied, despite its increasing importance as an essential functional endpoint for clinical trials and emerging therapies in retinal diseases.
Klaudia Birner, Leonard M. Coulibaly, Johannes Schrittwieser, Irene Steiner, Hamza Mohamed, Simon Schürer‐Waldheim, Markus Gumpinger, Hrvoje Bogunovic, Ursula Schmidt‐Erfurth, Gregor S. Reiter   +9 more
wiley   +1 more source

Abundant lipid and protein components of drusen. [PDF]

PLoS ONE, 2010
Drusen are extracellular lesions characteristic of aging and age-related maculopathy, a major retinal disease of the elderly. We determined the relative proportions of lipids and proteins in drusen capped with retinal pigment epithelium (RPE) and in RPE ...
Lan Wang, Mark E Clark, David K Crossman, Kyoko Kojima, Jeffrey D Messinger, James A Mobley, Christine A Curcio   +6 more
doaj   +1 more source

Quantitative and Qualitative Evaluation of Explainable Deep Learning Methods for Ophthalmic Diagnosis [PDF]

arXiv, 2020
Background: The lack of explanations for the decisions made by algorithms such as deep learning has hampered their acceptance by the clinical community despite highly accurate results on multiple problems. Recently, attribution methods have emerged for explaining deep learning models, and they have been tested on medical imaging problems.
arxiv  

Semaglutide and non‐arteritic anterior ischaemic optic neuropathy: Review and interpretation of reported association

Acta Ophthalmologica, EarlyView.
Abstract This review covers a seminal study of the relation between exposure to the glucagon‐like peptide 1 (GLP‐1) agonist semaglutide and incident non‐arteritic anterior ischaemic optic neuropathy (NAION) in a neuro‐ophthalmology clinic setting, subsequent studies in unselected populations, a meta‐analysis of clinical trials and pathophysiology ...
Abdullah Amini, Steffen Hamann, Michael Larsen   +2 more
wiley   +1 more source

Early Detection of Incipient Retinal Pigment Epithelium Atrophy Overlying Drusen with Fundus Autofluorescence vs. Spectral Domain Optical Coherence Tomography

Journal of Ophthalmology, 2020
Purpose. This study aims to find out which tool, fundus autofluorescence (FAF) or spectral domain optical coherence tomography (SD-OCT), is more sensitive in detecting retinal pigment epithelium (RPE) demise overlying drusen and can, therefore, help ...
Anabel Rodríguez, Marc Biarnés, Rosa M. Coco-Martin, Anna Sala-Puigdollers, Jordi Monés   +4 more
doaj   +1 more source

Clinical analysis of buried optic nerve drusen with optical coherence tomography examination [PDF]

, 2013
AIM: To explore the specific image of buried optic nerve drusen during optical coherence tomography(OCT)examination. METHODS: A retrospective study was made on 6 patients with buried optic nerve drusen(6 eyes)diagnosed by fundus fluorescein angiography ...
Bo Pan, Juan Liu, Wei-Gang Xu
core   +1 more source