Results 31 to 40 of about 3,061,023 (255)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Prediction for Humidity Adjustment Factor and Dry-Wet Cycle Reduction Factor of Resilient Modulus of Subgrade Soil Based on ANN

Zhongwai Gonglu
Existing methods for determining the humidity adjustment factor and dry-wet cycle reduction factor of the resilient modulus of subgrade soil are mostly based on laboratory tests that consume a large amount of manpower and time, and the prediction ...
WANG Xufeng, FU Wei, PENG Junhui, HU Jiankun, ZHANG Junhui, LI Zhiguang   +5 more
doaj   +1 more source

Study on Mix Proportion Design Based on Strength and Sulfate Resistance of 100% Recycled Aggregate Concrete

Buildings, 2022
This paper presents the mechanical properties of 100% recycled aggregate concrete (RAC), and the results and analysis of the dry–wet cycle accelerated sulfate attack test. The results show that recycled concrete aggregate (RCA) can replace the coarse and
Haizhou Li, Jianping Liu, Fujiao Chu, Lu Zhang   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Effects of Acidic Environment on Dynamic Mechanical Properties and Porosity Evolution Characteristics of Coal

Shock and Vibration, 2021
Coal pillars left in coal mines are often subjected to long-term submersion by groundwater and chemical solutions and are susceptible to deterioration and even destabilization damage under dynamic load disturbance.
Shuang Gong, Xiaojun Li, Wen Wang, Shibin Yao, Juan Liu, Dengyun Niu   +5 more
doaj   +1 more source

Wet/dry cycle durability of polyphenylene ionomer membranes in PEFC

Journal of Power Sources Advances, 2021
The mechanical durability of our hydrocarbon polymer electrolyte membrane, poly(sulfophenylene quinquephenylene) (SPP-QP) or polyphenylene ionomer, was evaluated in wet/dry cycle tests in fuel cells according to the US-DOE protocol, where the effect of ...
Toshiki Tanaka, Haruhiko Shintani, Yasushi Sugawara, Akihiro Masuda, Nobuyuki Sato, Makoto Uchida, Kenji Miyatake   +6 more
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Estimation of atmospheric nutrient inputs to the Atlantic Ocean from 50 degrees North to 50 degrees South based on large-scale field sampling: Fixed nitrogen and dry deposition of phosphorus [PDF]

, 2010
Atmospheric nitrogen inputs to the ocean are estimated to have increased by up to a factor of three as a result of increased anthropogenic emissions over the last 150 years, with further increases expected in the short- to mid-term at least.
Baker, A.R., C. Adams, Jickells, TJ, Jickells, T.D., Ganzeveld, L.N., T. D. Jickells, Lesworth, T., T. Lesworth, A. R. Baker, Ganzeveld, L, Adams, C., Baker, AR, Lesworth, T, L. Ganzeveld, Adams, C   +14 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Strength characteristics and microstructure of silty sand improved by red mud, lime and fly ash under dry-wet cycle

Case Studies in Construction Materials
Red mud is a kind of solid waste, which can be used as engineering roadbed filler after proper treatment. Due to the special physical and chemical properties of red mud, such as high liquid limit and high plasticity index, it may affect the stability of ...
Song Yin, Siyue Zheng, Xinming Li, Zhiliu Wang, Pan Yan, Ya He, Yuru Li   +6 more
doaj   +1 more source