Results 101 to 110 of about 42,739 (239)

DRY EYE SYNDROME: PROBLEMS OF DIAGNOSIS AND TREATMENT

Медицина в Кузбассе
Dry eye syndrome (DES) is widespread throughout the world's population. In recent years, a large number of research papers have been devoted to the causes, methods of diagnosis and treatment of this problem.
Светлана Ивановна Елгина, Евгения Алексеевна Созуракова, Елена Владимировна Рудаева, Наталья Степановна Черных, Кира Борисовна Мозес, Яэль Центер, Елизавета Евгеньевна Паньшина, Елизавета Дмитриевна Егорова, Алена Ивановна Пахолкина, Сона Ханларовна Мазанова   +9 more
doaj  

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source

The impact of systemic long‐term medications for the development of age‐related macular degeneration

Acta Ophthalmologica, EarlyView.
Abstract Purpose Age‐related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long‐term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and ...
Hanna Heloterä, Reijo Sund, Toni Rikkonen, Kai Kaarniranta   +3 more
wiley   +1 more source

Repeatability of keratometry depending on tear film osmolarity

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the repeatability of keratometry and astigmatism measurements of patients depending on the tear film osmolarity using three different devices. Methods In this study, 97 eyes of 97 patients with a mean age of 64.92 ± 12.07 years received three repeated measurements with the IOLMaster 700 (Carl Zeiss Meditec, Jena, Germany),
David Schneider, Klemens Paul Kaiser, Petra Davidova, Thomas Kohnen, Tyll Jandewerth   +4 more
wiley   +1 more source

Integrating Sr isotopes, microchemistry, and genetics to reconstruct Salmonidae species and life history

Archaeometry, EarlyView.
Abstract Recent approaches to fisheries research emphasize the importance of the coproduction of knowledge in building resilient and culturally mindful fisheries management frameworks. Despite widespread recognition of the need for Indigenous knowledge and historical reference points as baseline data, archaeological data are rarely included in ...
Ross Salerno, Remi Murdoch, Joanna Elmore, Taylor Wilcox, Jens Hegg, Catherine S. Austin, Michael LeMoine, Jade Luckhurst, Alexandra K. Fraik, Molly Carney   +9 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Deployment of Perioperative Nurses From Their Clinical Specialty During the COVID‐19 Pandemic: An Integrative Review

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To identify the available records surrounding the deployment of perioperative nurses into differing clinical settings during the COVID‐19 pandemic. Design Integrative review methodology. Methods Quality appraisal of each record was conducted using a modified Critical Appraisal Skills Programme checklist.
Jennifer Crump, Debra Jackson, Maricris Algoso, Kath Peters   +3 more
wiley   +1 more source

A Tale of Two Conditions: 50 Years of Chronic Illness and Cancer From a Nursing Perspective

Journal of Advanced Nursing, EarlyView.
ABSTRACT Introduction In this commentary, I consider the disparity between the care we see as a necessity for cancer patients and the lack of care we afford to many persons with chronic disease. Background I ground my arguments in my own clinical practice and research experiences over a 50‐year period augmented by reference to available literature ...
Sally Thorne
wiley   +1 more source

Desired and Feared Identities and Their Role in Occupational Identity Regulation

Journal of Management Studies, EarlyView.
Abstract This paper extends theory by showing how occupational identity regulation operates jointly through both desired and feared identities which, in combination, enforce normative control. Taking a narrative identity perspective and drawing on an ethnographic and interview‐based study of veterinarians, we make three principal contributions to our ...
Sarah Page‐Jones, Andrew D. Brown
wiley   +1 more source