Results 101 to 110 of about 31,424 (285)

Outcome parameters in studies investigating dry eye disease: A systematic literature review

Acta Ophthalmologica, EarlyView.
Abstract The development of effective therapeutics for dry eye disease (DED) is challenging due to its complex pathophysiology, heterogeneous patient presentation and the significant failure rate of previous clinical development programs. This underlines the importance of the selection of appropriate endpoints for clinical trials.
Viktoria Pai, Doreen Schmidl, Liudmyla Petric, Patrick Janku, Theresa Lindner, Ulrich Graf, Jacqueline Chua, Leopold Schmetterer, Gerhard Garhöfer   +8 more
wiley   +1 more source

Tear Film Break-up Time in Bipolar Disorder.

Iranian Journal of Psychiatry, 2012
Ocular dryness is a well-recognized adverse side effect of many topical and systemic medications. In psychiatry, patients who have consumed such drugs as lithium carbonate and sodium valproate frequently experience dry eye symptoms.
Parvin Dibajnia, Mohadeseh Mohammadinia, Maryam Moghadasin, Mohammad Aghazade Amiri   +3 more
doaj   +2 more sources

Clinical indicators of dry eye severity nursing outcome in intensive care unit

Revista Latino-Americana de Enfermagem
Objective: to verify the extent of impairment of the clinical indicators of the nursing outcome Dry Eye Severity in patients admitted to the Intensive Care Unit. Method: cross-sectional, descriptive study developed with 206 patients. Based on the result
Raffaela Patrícia da Silva Soares, Ana Paula Nunes de Lima Fernandes, Fabiane Rocha Botarelli, Jéssica Naiara de Medeiros Araújo, Jéssica de Araújo Olímpio, Allyne Fortes Vitor   +5 more
doaj   +3 more sources

Ophthalmologic manifestations in patients with inflammatory bowel disease

Intestinal Research, 2017
Background/Aims: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), has been reported to have various ophthalmologic manifestations.
Hye Jin Lee, Hyun Joo Song, Jin Ho Jeong, Heung Up Kim, Sun-Jin Boo, Soo-Young Na   +5 more
doaj   +1 more source

Papel de la osmolaridad en el desarrollo de patología inflamatoria de la superficie ocular [PDF]

, 2016
Revisión sobre el papel que juega la osmolaridad en las patologías inflamatorias de la superficie ocular centrándonos principalmente en el ojo seco. Abarca desde el 1980 hasta la actualidad. Se describen las diferentes capas de la superficie ocular y los
Salgado Arrabal, Noemí
core  

What is the incidence and clinical significance of dry eye disease in patients treated with immune checkpoint inhibitors? A systematic review and meta‐analysis of ocular immune‐related adverse events

Acta Ophthalmologica, EarlyView.
Abstract Purpose Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but may cause immune‐related adverse events (irAEs), including dry eye disease (DED). This study aimed to quantify the incidence of ICI‐associated DED and to evaluate factors contributing to variability across studies.
Kai‐Yang Chen, Hoi‐Chun Chan, Chi‐Ming Chan   +2 more
wiley   +1 more source

Using Social Media Listening to Characterize the Flare Lexicon in Patients with Sjögren’s Disease

Rheumato
Background/Objectives: Sjögren’s disease (SjD) flares are incompletely understood. The patient perspective is critical to closing this gap. This retrospective social media listening (SML) study characterized the flare lexicon within the online Reddit SjD
Chiara Baldini, Maurice Flurie, Zachary Cline, Colton Flowers, Coralie Peter Bouillot, Linda J. Stone, Lauren Dougherty, Christopher DeFelice, Maria Picone   +8 more
doaj   +1 more source

Fraser of cryptophthalmosis syndrome: A case report [PDF]

, 2004
Fraser or cryptophthalmos syndrome is a rare autosomal recessive disorder characterized by major features such as cryptophthalmos, syndactyly, and abnormal genitalia. Consanguinity is reported in 15-24.8% of the cases.
Adibi, B., Golalipour, M.-J., Haidary, K., Khoury, E.   +3 more
core  

Randomized, single‐centre, double‐blinded repeated dose investigation of safety and tolerability of ocular administrations of a novel silica eye drop product in healthy volunteers

Acta Ophthalmologica, EarlyView.
Abstract Purpose Managing ocular diseases often requires frequent eye drop administration, which can challenge patient compliance. A long‐acting eye drop technology using an amorphous synthetic silica composite was developed to address this. Our study aimed to assess the safety and tolerability of the Silica Eye Drop platform in healthy volunteers over
Aleksandra Poluianova, Marceline N. Akieh‐Pirkanniemi, Arto Hartikainen, Hanna Arstila, Kai Kaarniranta, Lasse Leino   +5 more
wiley   +1 more source

Aniridia‐associated keratopathy: Clinical and molecular mechanisms of disease progression and emerging therapeutic targets

Acta Ophthalmologica, EarlyView.
Abstract Congenital aniridia is a rare genetic disorder primarily caused by pathogenic variants of the PAX6 gene. It leads to various panocular anomalies, including aniridia‐associated keratopathy (AAK). This review highlights recent insights into its pathogenesis, focusing on clinical staging, microstructural changes in the cornea and molecular ...
N. Szentmáry, S. Suiwal, M. Amini, F. N. Fries, A. Náray, L. Latta, Z. Li, S. Li, S. Liu, S. L. Hsu, S. Kundu, G. Tóth, S. Trusen, J. Zimmermann, B. Seitz, B. Käsmann‐Kellner, Z. Hoxha, A. Langenbucher, O. Stachs, M. Cortón‐Perez, K. Tory, A. Csorba, Z. Z. Nagy, M. C. Acosta, J. Gallar, M. Csidey, E. Maka, T. Stachon   +27 more
wiley   +1 more source