Results 51 to 60 of about 48,221 (295)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Research Progress on Technology Parameter Optimization of High-speed Dry Gear Hobbing

Journal of Harbin University of Science and Technology, 2022
Gear hobbing technology is one of the most widely used gear processing technologies. The emergence and gradual maturity of high-speed dry gear hobbing provide the technical conditions for the realization of green and energy-saving processing and ...
CHENG Yao-nan, MA Chun-jie, ZHANG Jian-yu, XIN Li-ming, WANG Xin-yu   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

On dry machining of AZ31B magnesium alloy using textured cutting tool inserts

Journal of Magnesium and Alloys
Magnesium alloys have many advantages as lightweight materials for engineering applications, especially in the fields of automotive and aerospace. They undergo extensive cutting or machining while making products out of them.
Shailendra Pawanr, Kapil Gupta
doaj   +1 more source

Influence of graphene reinforced sunflower oil on thermo-physical, tribological and machining characteristics of inconel 718

Journal of Materials Research and Technology, 2021
Owing to the extreme heat generated during Inconel 718 machining, the application of a minimum quantity lubrication (MQL) strategy is restricted to mild cutting conditions.
Mohd Danish, Munish Kumar Gupta, Saeed Rubaiee, Anas Ahmed, Murat Sarikaya   +4 more
doaj   +1 more source

Performance of dehumidifier drying machine for soybean seeds drying

IOP Conference Series: Earth and Environmental Science, 2022
Abstract The number of soybean consumption in Indonesia has increased every year. However, the amount of domestic production is still insufficient and continues to decline, so imports must be carried out. A strategy used to increase soybean production is by using a good quality of seeds.
B Susilo, M B Hermanto, R Damayanti, E D E Putri   +3 more
openaire   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Optimization and analysis of cutting parameters using cryogenic media in machining of high strength alloy steel [PDF]

, 2013
In this research, liquid Argon is used as a cryogenic media to optimize the cutting parameters for evaluation of tool flank wear width of Tungsten Carbide Insert (CNMG 120404-WF 4215) while turning high strength alloy steel.
Ali, Liaqat, Butt, Shahid, Jaffery, Husain, Jaffery, Mehdi, Khan, Mushtaq, Tahir, Waseem   +5 more
core  

Energy-Efficient Machining Process Analysis and Optimisation Based on BS EN24T Alloy Steel as Case Studies [PDF]

, 2019
Computer Numerical Controlled (CNC) machining, which is one of the most widely-deployed manufacturing techniques, is an energy-intensive process.
Caires Moreira, Lorena, Fitzpatrick, Michael, Li, Weidong, Lu, Xin   +3 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source