Results 191 to 200 of about 258,625 (255)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Exploring the Role of Skin Microbiota in Autoimmune Skin Diseases from a Bidirectional Mendelian Randomization Perspective. [PDF]

Clin Cosmet Investig Dermatol
Wang J, Wang X, Tao X, Yang Q, Zhang M, Wang Y, Liu S.   +6 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Bioinspired Reversible Adhesive with High Strength for Wearable Electronics under Diverse Environments. [PDF]

Research (Wash D C)
Wu Y, Liu H, Tian H, Li X, Wang D, Sun B, Zhao Q, Zhang J, Lan T, Liu G, Chen X, Wang C, Shao J.   +12 more
europepmc   +1 more source

Skin examination in extreme conditions. [PDF]

Acta Biochim Pol
Igielska-Kalwat J.
europepmc   +1 more source

Skin Microbiota Diversity Is Associated with Biophysical Properties Across Healthy Human Skin Types. [PDF]

Microorganisms
Kadoya R, Kondo A, Matsukawa A, Kuribayashi A, Uemura E, Tanaka H.   +5 more
europepmc   +1 more source

Variations in cow milk and teat skin microbiota across the lactation cycle with intramammary cephalosporin use at dry-off. [PDF]

Appl Environ Microbiol
Van Beeck W, Lemos MLP, Niesen AM, Finnegan P, Shih TM, Ho A, Rossow HA, Marco ML.   +7 more
europepmc   +1 more source

The drying of hides and skins [PDF]

, 1952
openaire  

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Skin Aging and Dry Skin

Journal of Dermatology, 2004
AbstractSkin aging appears to be the result of both scheduled and continuous “wear and tear” processes that damage cellular DNA and proteins. Two types of aging, chronological skin aging and photoaging, have distinct clinical and histological features. Chronological skin aging is a universal and inevitable process characterized primarily by physiologic

exaly   +3 more sources