Results 71 to 80 of about 11,781,139 (255)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Methods for Assessing External Sulfate Attack on Cement-Based Specimens

Applied Sciences
This paper presents two original methods for monitoring and evaluating concrete specimens/structures affected by external sulfate attack (ESA). The first is a drying method developed to assess the penetration depth of sulfate ions in a concrete structure,
Othman Omikrine Metalssi, Marc Quiertant, Mike Jabbour, Véronique Baroghel-Bouny   +3 more
doaj   +1 more source

Kiln drying behavior utilizing drying rate of lumber from six fast-growth plantation species in Costa Rica [PDF]

, 2016
Artículo científicoThe objective was to study the effect of the drying time and moisture content variations on the drying rate during kiln drying. The moisture content is a good predictor of the variation in drying rate; to determine the drying rate, the
Moya-Roque, Róger, Cynthia Salas, Tenorio-Monge, Carolina, Carolina Tenorio, Róger Moya, Salas-Garita, Cynthia   +5 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Effects of Drying Methods on Morphological Characteristics, Metabolite Content, and Antioxidant Capacity of Cordyceps sinensis

Foods
Cordyceps sinensis is a rare and endangered medicinal herb in China and a typical medicinal and food plant. Most of the research related to Cordyceps sinensis focuses on its pharmacological effects, artificial cultivation and clinical applications ...
Mengjun Xiao, Tao Wang, Chuyu Tang, Min He, Yuling Li, Xiuzhang Li   +5 more
doaj   +1 more source

Contact drying of particulate pharmaceuticals: modelling and simulation [PDF]

, 2010
In order to give a concrete response to the need of predictive contact drying simulation tools in pharmaceutical industry, simulation programs for contact drying of pharmaceutical powders were developed in this thesis work.
Intelvi, Marco
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Evaluation of rheological properties of pork myofibrillar protein gel and physicochemical and textural properties of low-fat model sausages containing various levels of chickpea powder dried by different methods [PDF]

Animal Bioscience
Objective This study evaluated the rheological properties of pork myofibrillar protein (MP) gels, as well as the physicochemical and textural properties of low-fat model sausages (LFMS) formulated with various levels of chickpea powder (CPP) processed ...
Min Jae Kim, Koo Bok Chin
doaj   +1 more source

Beyond freeze-drying of biologics: vacuum-foam drying and spray freeze-drying [PDF]

, 2018
[EN] The complexity of biotherapeutics in development continues to increase as our capability in discovery and recombinant technology improves. While safety and efficacy remain the two critical aspects of all therapeutics, ensuring adequate stability is ...
Plitzko, M., Lukas, A., Bhatnagar, B., Hageman, M.J., Ohtake, S., Balthazor, B., Tchessalov, S., Luy, B., Langford, A.   +8 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source