Results 41 to 50 of about 314,284 (266)

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Effects of Different Drying Methods on Rice Quality Before and After Soaking

Shipin gongye ke-ji
In order to explore the effects of different rice drying methods on physicochemical properties and taste quality of rice before and after soaking, the same variety of japonica rice after natural drying and hot air drying was used as the main raw material
Zhi WEI, Tingting PAN, Jiayu LI, Jinlong ZHAO, Aihua ZHAI   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Physical Aspects, Phytochemical Profiles, and Nutritional Properties of Lemon (Citrus limon) Slices Under Different Drying Technologies

Foods
Dried lemon slices (LSs) have become increasingly popular as a healthful beverage when infused in hot water. This study examined the effects of freeze drying (FD), hot air drying (HAD), heat pump drying (HPD), and far-infrared drying (FID) on the quality
Zhirong Wang, Qingqing Fu, Guijie Hao, Yuanwei Gu, Tianqi Sun, Lu Gao, Bo Wang, Shuai Wang, Xiangfeng Zheng, Zhenquan Yang, Shengqi Rao   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effects of Various Drying Techniques on the Quality Attributes and Metabolite Profiles of Flammulina velutipes (Fruiting Body) Based on Non-Target Metabolomics

Foods
Flammulina velutipes (Golden Needle Mushroom, F. velutipes) undergoes rapid postharvest deterioration characterized by browning and decay. Drying effectively extends its shelf life and processing window.
Wenchan Yang, Yue Su, Huinan Zhou, Lujuan Wang, Danhua Chen, Fengyun Zhao, Jianmin Yun, Xuerui Wang   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Influence of the Drying Process on the Dissolution Time of Concentrated Chinese Medicine Pills: Roles of Textural Properties and Water Migration

Pharmaceutics
Objectives: Concentrated pills, as a modernization and upgrade of traditional pills, have achieved significant advancements in dosage form. However, their extended disintegration and dispersion times have become a major limitation to their therapeutic ...
Xiaojun Wang, Qinmin Meng, Xiaojian Luo, Yao Zhang, Jing Yang, Xiaoyong Rao, Yingming Zhang, Haowei Lu, Yan He, Wei Liu   +9 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of Different Drying Method on the Nutritional Quality and Antioxidant Activity of Jiangyong Fragrant Ginger Based on Principal Component Analysis

Shipin gongye ke-ji
To comprehensively evaluate the effects of drying methods on the nutritional quality and antioxidant activity of Jiangyong fragrant ginger, seven different drying methods including natural drying (ND), hot air drying (HAD), infrared drying (ID ...
Xinsheng XIAO, Wenjun ZHOU, Meitao FENG, Jialing LI, Liyan JIANG   +4 more
doaj   +1 more source