Results 51 to 60 of about 314,886 (266)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Physical Aspects, Phytochemical Profiles, and Nutritional Properties of Lemon (Citrus limon) Slices Under Different Drying Technologies

Foods
Dried lemon slices (LSs) have become increasingly popular as a healthful beverage when infused in hot water. This study examined the effects of freeze drying (FD), hot air drying (HAD), heat pump drying (HPD), and far-infrared drying (FID) on the quality
Zhirong Wang, Qingqing Fu, Guijie Hao, Yuanwei Gu, Tianqi Sun, Lu Gao, Bo Wang, Shuai Wang, Xiangfeng Zheng, Zhenquan Yang, Shengqi Rao   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Influence of the Drying Process on the Dissolution Time of Concentrated Chinese Medicine Pills: Roles of Textural Properties and Water Migration

Pharmaceutics
Objectives: Concentrated pills, as a modernization and upgrade of traditional pills, have achieved significant advancements in dosage form. However, their extended disintegration and dispersion times have become a major limitation to their therapeutic ...
Xiaojun Wang, Qinmin Meng, Xiaojian Luo, Yao Zhang, Jing Yang, Xiaoyong Rao, Yingming Zhang, Haowei Lu, Yan He, Wei Liu   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of Various Drying Techniques on the Quality Attributes and Metabolite Profiles of Flammulina velutipes (Fruiting Body) Based on Non-Target Metabolomics

Foods
Flammulina velutipes (Golden Needle Mushroom, F. velutipes) undergoes rapid postharvest deterioration characterized by browning and decay. Drying effectively extends its shelf life and processing window.
Wenchan Yang, Yue Su, Huinan Zhou, Lujuan Wang, Danhua Chen, Fengyun Zhao, Jianmin Yun, Xuerui Wang   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Effect of Different Drying Method on the Nutritional Quality and Antioxidant Activity of Jiangyong Fragrant Ginger Based on Principal Component Analysis

Shipin gongye ke-ji
To comprehensively evaluate the effects of drying methods on the nutritional quality and antioxidant activity of Jiangyong fragrant ginger, seven different drying methods including natural drying (ND), hot air drying (HAD), infrared drying (ID ...
Xinsheng XIAO, Wenjun ZHOU, Meitao FENG, Jialing LI, Liyan JIANG   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Drying Method on Sulfur Dioxide Content in Edible Mushrooms and Endogenous Transformation Factors

Shipin gongye ke-ji
In this study, dietary risk assessment of sulfur dioxide content in both fresh and dried commercially available edible mushrooms (Tremella fuciformis, Lentinus edodes, and Agaricus blazei) was conducted through risk quotient and point assessment methods.
Yiming TIAN, Chun XU, Qiao YANG, Xinfang ZHANG, Songlin CHANG, Jiali REN   +5 more
doaj   +1 more source