Connexin-43 Restoration Alleviates Desmosomal Arrhythmogenic Cardiomyopathy. [PDF]
Circ Heart FailZhang J +18 more
europepmc +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
Protocol for spatial profiling of immune cells in the mouse cornea and conjunctiva using NanoString GeoMx DSP and nCounterPro platforms. [PDF]
STAR ProtocKim L, Ramasamy K, Sharma A.
europepmc +1 more source
Impact of Oral Sebetralstat on Anxiety Associated With Hereditary Angioedema Attacks
Clinical &Experimental Allergy, EarlyView.In the phase 3 KONFIDENT trial of oral sebetralstat for on‐demand treatment of hereditary angioedema attacks, many attacks induced moderate‐to‐extreme anxiety. Sebetralstat reduced anxiety versus placebo; time to reductions agreed with trial endpoints, such as time to beginning of symptom relief.
Timothy Craig +24 more
wiley +1 more source
Effect of combined application of premixed bioceramic paste and diode laser in vital pulp therapy: an immunohistochemical randomized controlled split-mouth in vivo animal experiment. [PDF]
Restor Dent EndodSalama MA +4 more
europepmc +1 more source
Child &Family Social Work, EarlyView.ABSTRACT Care leavers often encounter considerable health and well‐being challenges, underscoring the need for continued support into early adulthood. This small‐scale mixed‐methods study explored the health, well‐being and extended care experiences of participants in the South Australian Next Steps pilot program for residential care leavers, assessed ...
Sally‐Ann Keipert +3 more
wiley +1 more source
Absent the pre-B cell receptor checkpoint, the B-1a immunoglobulin CDR-H3 repertoire normalizes by convergent selection. [PDF]
Front ImmunolVaz LTC +6 more
europepmc +1 more source
Molecular Basis and Clinical Spectrum of WNT10A‐Related Oligodontia
Clinical Genetics, EarlyView.Cellular Mechanism behind WNT10A phenotypes. ABSTRACT WNT10A mutations, a major genetic determinant of dental agenesis and ectodermal dysplasia, exert profound effects on craniofacial development. Although classified as rare disorders, these mutations account for more than half of oligodontia cases, reflecting their critical role.
Perennes Elise +5 more
wiley +1 more source
A frameshift variation in the DSP gene causes a novel subtype of atypical epidermolytic palmoplantar keratoderma: Case report. [PDF]
Front Med (Lausanne)Lin C +10 more
europepmc +1 more source
Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source