Results 151 to 160 of about 102,564 (236)

Comparative species distribution model framework for marine conservation and its application to loggerhead turtles in the Mediterranean

open access: yesConservation Biology, EarlyView.
Abstract Modeling species distributions in dynamic pelagic environments remains challenging, particularly for wide‐ranging and highly mobile species when there is limited guidance on model performance. This limitation constrains the effective use of species distribution models (SDMs) in marine conservation, where robust and transferable predictions are
E. Pasanisi   +32 more
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

open access: yesThe FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati   +4 more
wiley   +1 more source

From productive coupling to catalytic commitment: An evolutionarily tuned interdomain connector in Leishmania Aha1 orchestrates Hsp90 activation

open access: yesThe FEBS Journal, EarlyView.
LbAha1 activates LbHsp90 through a multistep mechanism in which productive N‐domain docking precedes ATP‐driven rearrangement and linker ordering. The LbAha1 linker transitions from a flexible to helical state, stabilizing an asymmetric, catalytically competent closed complex.
Paulo Roberto Dores‐Silva   +9 more
wiley   +1 more source

Real‐World Experience With Emicizumab for Haemophilia A From the Physician Perspective in a Real‐World Clinical Setting

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Emicizumab is a bispecific antibody approved for prophylaxis in people with haemophilia A (PwHA). Aim To describe from the physician perspective the characteristics and treatment experiences of PwHA receiving emicizumab. Methods The Adelphi Real World Haemophilia Disease Specific Programme is a cross‐sectional, retrospective data ...
Michael Recht   +7 more
wiley   +1 more source

Reduced-DSP 200G/λ low-voltage slow-light silicon modulator enabled by built-in EO equalizer. [PDF]

open access: yesNat Commun
Kawahara K   +6 more
europepmc   +1 more source

Poorly differentiated lung adenocarcinomas with concurrent ALK and CD30 expression: a diagnostic pitfall mimicking ALK‐positive anaplastic large‐cell lymphoma

open access: yesHistopathology, EarlyView.
Poorly differentiated lung adenocarcinomas with concurrent anaplastic lymphoma kinase (ALK) and CD30 expression closely mimic ALK‐positive anaplastic large‐cell lymphoma, creating a significant diagnostic pitfall. Accurate classification requires comprehensive integration of clinical, radiologic, morphologic, immunophenotypic and molecular findings ...
Jietian Jin   +6 more
wiley   +1 more source

Familial Dilated Cardiomyopathy Associated with a Desmoplakin Variant: A Case Report. [PDF]

open access: yesActa Cardiol Sin
Lin EY   +5 more
europepmc   +1 more source

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