Results 181 to 190 of about 24,143 (297)
The selective oxidation of primary amines to generate nitriles provides a cost‐effective and atom‐economical synthetic approach that avoids the formation of harmful byproducts. However, achieving high yields under mild conditions remains challenging, due to the difficulty in efficiently activating the α‐CH bonds of amines and the multiple competing ...
Tsukino Ishizaki +2 more
wiley +1 more source
DualPG-DTA: A Large Language Model-Powered Graph Neural Network Framework for Enhanced Drug-Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting In Vivo Anti-Leukemia Activity. [PDF]
Chen Y +7 more
europepmc +1 more source
The metadata ecosystem and AI: Enabling FAIR and AI‐ready data
Abstract Reproducibility is a foundational tenet of science. As artificial intelligence (AI) becomes increasingly embedded across science, the need to accurately document the provenance, structure, and behavior of training data, models, and workflows grows correspondingly. Metadata, understood as explicit and structured knowledge about data and related
Jane Greenberg +5 more
wiley +1 more source
Clonal hematopoiesis dynamics influences long-term outcomes of follicular lymphoma: Results from FIL FOLL12 trial. [PDF]
Maher N +40 more
europepmc +1 more source
Abstract Background Online adaptive radiotherapy (ART) relies on cone‐beam computed tomography (CBCT) imaging for daily treatment adaptation, but CBCT's physical limitations can compromise contour delineation and dose calculation accuracy. The relationship between image quality metrics and clinical ART workflow accuracy remains unclear.
Sunhwa Kim +5 more
wiley +1 more source
InSb, a narrow‐bandgap semiconductor with high carrier mobility, is promising for thermoelectric energy conversion but suffers from high lattice thermal conductivity and strong bipolar conduction. Here, in situ interface engineering using Co2O3 nanoprecursors forms hierarchical CoSbx/In2O3/CoSb3 heterostructures that enhance phonon scattering and ...
Jiwu Xin +10 more
wiley +1 more source
Remodelling and the fate of bone grafts in shoulder instability surgery. [PDF]
Remedios S, Karpyshyn J, Wong I.
europepmc +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
dMMR killer: A conditional suicide gene that preferentially kills DNA mismatch repair-deficient cells. [PDF]
Saito S +4 more
europepmc +1 more source
ABSTRACT Objectives Both psychosocial stress and current infection can increase the likelihood of reactivation of latent Epstein–Barr virus (EBV). Pregnancy and infection with SARS‐CoV‐2 can be stressful and modulate immune function. However, it is unknown how SARS‐CoV‐2 infection and stress further interact among postpartum women to affect EBV antigen
Emma Anastasi +18 more
wiley +1 more source

