ABSTRACT Background Differentiating demyelinating from axonal polyneuropathies helps for accurate diagnosis and treatment. However, the current clinical tools lack sensitivity to confirm demyelination in peripheral nerves, particularly for proximal nerves.
Jesus E. Fajardo +8 more
wiley +1 more source
Diffusion MRI of the Body: Beyond PGSE‐EPI
ABSTRACT Diffusion magnetic resonance imaging (dMRI) is a widely used clinical imaging technique which is sensitive to changes in tissue microstructure including cellularity, perfusion, and tissue damage. DMRI has been used in whole‐body imaging as well as in targeted imaging of every major anatomical region.
Matthew T. Cherukara +6 more
wiley +1 more source
Intravenous Infusion of Mesenchymal Stem Cells Enhances Long-Tract Reorganization That Circumvents the Lesion in a Rat Staggered Hemisection Spinal Cord Injury Model. [PDF]
Obara H +12 more
europepmc +1 more source
Toward a Smart Learning Health System: An Ontology‐Based Framework
ABSTRACT Background Learning health system (LHS) frameworks have been presented in multiple forms, but there is no standardized representation that captures both their core concepts and the relationships among them. This limits their practical use by health services seeking to design, implement, and evaluate LHS capabilities in changing sociotechnical ...
Meg Ma, Ping Yu, Louise D. Hickman
wiley +1 more source
Methodological Evolution of Diffusion MRI in Chronic Pain: A Narrative Review. [PDF]
Li H, Wang Y, Li M, Yang H, Qiu Z, Xu X.
europepmc +1 more source
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang +5 more
wiley +1 more source
Automated Surface-Based Segmentation of Deep Gray Matter Regions Based on Diffusion Tensor Images Reveals Unique Age Trajectories Over the Healthy Lifespan. [PDF]
Little G, Acosta-Franco JA, Beaulieu C.
europepmc +1 more source
Neuropathic Pain: From Mechanisms to Therapeutic Interventions
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai +8 more
wiley +1 more source
Imaging study of white matter microstructural damage and glymphatic system dysfunction in patients with primary insomnia: a combined analysis based on PSMD, DTI-ALPS, and EPVS. [PDF]
Pan Q +9 more
europepmc +1 more source

