Results 41 to 50 of about 48,188 (262)

A Site‐Aware Representation Learning Framework For Unified Molecular Interaction Modeling and Generative Design

Advanced Science, EarlyView.
MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo, Qianqian Zhang, Chenhao Wang, Zhiheng Yi, Alex Jinpeng Wang, Jing Tang, Min Li   +6 more
wiley   +1 more source

Meningeal Lymphatic LTBR Deficiency Links Spinal Cord Injury to Secondary Brain Pathology

Advanced Science, EarlyView.
Spinal cord injury (SCI) induces remote brain alterations beyond the injured spinal cord. This study links dysfunction of meningeal lymphatic vessels (mLVs) to neuroinflammation and neuronal injury after SCI. LTBR‐mediated lymphatic restoration improves meningeal lymphatic integrity and neurological outcomes, highlighting LTBR as a potential regulator ...
Yi Chen, Yu Tang, Chengpeng Hu, Xiaoyan Duan, LingXia Min, Boya Cong, Chao Ma, Mingliang Tan, Ya Luo, Pengfei Wei, Minpeng Xu, Zhou Feng, Jingming Hou   +12 more
wiley   +1 more source

USO COMBINADO DE RESONANCIA MAGNÉTICA FUNCIONAL (fMRI) Y TRACTOGRAFIA PARA SELECCIONAR TRACTOS ESPECÍFICOS DE SUSTANCIA BLANCA: EXPERIENCIA PRELIMINAR

Revista Chilena de Radiología
La tractografía es una técnica de postprocesamiento de imágenes de resonancia magnética, que permite visualizar tractos de sustancia blanca. La selección de tractos específicos es un tema actual de investigación a nivel mundial.
Gonzalo Rojas C, Jorge Cordovez M, Marcelo Gálvez M, Jaime Cisternas E, Takeshi Asahi K, Eduardo Bravo C   +5 more
doaj   +1 more source

AS‐pHopt: An Optimal pH Prediction Model Enhanced by Active Site of Enzymes

Advanced Intelligent Discovery, EarlyView.
To address the low accuracy of enzyme optimal pH (pHopt) prediction, this study develops active site‐based pHopt (AS‐pHopt), a prediction model enhanced by active site information and pseudo‐label prediction. Integrating key structural and physicochemical features affecting enzyme pHopt, AS‐pHopt uses Evolutionary Scale Modeling (ESM)‐2 with active ...
Wenxiang Song, Xinmin Li, Hongbo Yu, Le Xiong, Guixia Liu, Weihua Li, Yun Tang   +6 more
wiley   +1 more source

Multimodal Characterization of Glymphatic‐Related Magnetic Resonance Imaging Markers in Huntington's Disease: A Multi‐Cohort Retrospective Study

Annals of Neurology, EarlyView.
Objective To characterize magnetic resonance imaging (MRI)‐based glymphatic surrogates in Huntington's disease (HD) using MRI measures of perivascular diffusivity and structural perivascular alterations across multiple large cohorts. Methods We analyzed 2,731 MRI sessions from 880 participants across 3 large retrospective HD cohorts.
Alexia Solomon, Zexi Wang, Francesco Sanvito, Zheng Zhou, Adys Mendizabal, Jingwen Yao   +5 more
wiley   +1 more source

Microstructure white matter changes and serum GFAP among different phenotypes of multiple sclerosis [PDF]

Romanian Journal of Neurology
Background. Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system (CNS). A patient’s degree of demyelination and axonal degeneration can only be roughly estimated based on clinical symptoms, neurochemical analysis or ...
Elsayed Orief, Samer Salama, Mohamed Elkhateeb, Ahmad El-Morsy   +3 more
doaj   +1 more source

Scoping literature review: Comparing MRI tractography methods for optic radiation analysis

The Anatomical Record, EarlyView.
Abstract Accurate tractography mapping of the optic radiations is essential to avoiding post‐operative visual field deficits in patients undergoing temporal lobe surgery. This literature review highlights the current landscape of MRI tractography methods that are used to delineate the optic radiations (ORs), with a particular focus on the anterior ...
Hriday Sahni, Cristina Schaurich, Lara Boyd, Claudia Krebs   +3 more
wiley   +1 more source

“Hands‐On” white matter anatomy: Using Air Anatomy gestures and tractography on simple brain sections to enhance teaching of white matter directions

Anatomical Sciences Education, EarlyView.
Abstract Teaching white matter (WM) anatomy to undergraduates is challenging. This is partly because WM fibers are oriented intricately and Klingler's dissection, the gold standard method used to demonstrate it, often requires time, advanced anatomical knowledge, and refined dissection skills.
Doris George Yohannan, Rohini Punja, Thomas Iype, Chandrasekharan Kesavadas, Bejoy Thomas, Kannanvilakom Govindapillai Umesan, Aswathy Maria Oommen, Usha Devi Keezhathil Bhargavi   +7 more
wiley   +1 more source

DTI-ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi-Modal MRI. [PDF]

Hum Brain Mapp
In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...
Sacchi L, Farruggio G, Bocca G, Carandini T, De Riz M, Ghezzi L, Pintus M, Pietroboni A, Boffa G, Scola E, Triulzi F, Bozzali M, Galimberti D, Cercignani M, Arighi A.   +14 more
europepmc   +2 more sources

The Role of Resilience in Coping with Negative Parental Behaviour

Acta Educationis Generalis, 2019
Introduction: Negative parental behaviour is among the significant risk factors that can have a negative impact on an individual’s development. In certain contexts, when appropriate protective factors are available, individuals deal with adversity better
Barnová Silvia, Tamášová Viola, Krásna Slávka   +2 more
doaj   +1 more source