Results 81 to 90 of about 194,537 (375)

A multiprover interactive proof system for the local Hamiltonian problem [PDF]

, 2014
We give a quantum interactive proof system for the local Hamiltonian problem on n qubits in which (i) the verifier has a single round of interaction with five entangled provers, (ii) the verifier sends a classical message on O(log n) bits to each prover,
Fitzsimons, Joseph, Vidick, Thomas
core   +2 more sources

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction. [PDF]

, 2017
BackgroundKnowledge of the three-dimensional (3D) infarct structure and fiber orientation remodeling is essential for complete understanding of infarct pathophysiology and post-infarction electromechanical functioning of the heart.
Bluemke, David A, Gai, Neville, Halperin, Henry, Herzka, Daniel A, McVeigh, Elliot R, Mori, Susumu, Pashakhanloo, Farhad, Trayanova, Natalia A, Zviman, Muz   +8 more
core   +1 more source

Paraspinal Muscle DTI Metrics Predict Muscle Strength

Journal of Magnetic Resonance Imaging, 2019
The paraspinal muscles play an important role in the onset and progression of lower back pain. It would be of clinical interest to identify imaging biomarkers of the paraspinal musculature that are related to muscle function and strength.
Elisabeth Klupp, B. Cervantes, Sarah Schlaeger, Stephanie Inhuber, Florian Kreuzpointer, A. Schwirtz, A. Rohrmeier, M. Dieckmeyer, D. Hedderich, M. Diefenbach, Friedemann Freitag, E. Rummeny, C. Zimmer, J. Kirschke, D. Karampinos, T. Baum   +15 more
semanticscholar   +1 more source

Disease Progression in Multiple System Atrophy: The ASPIRE Multi‐Modal Biomarker Study

Annals of Neurology, EarlyView.
Objective The objective of this study was to characterize changes in candidate biomarkers in early multiple system atrophy (MSA) and identify baseline predictors of faster progression. Methods This 1‐year, multicenter, prospective study assessed clinical, neuroimaging (3T‐magnetic resonance imaging [MRI], dopamine transporter single‐photon emission ...
Margherita Fabbri, Natalia del Campo, Wassilios G. Meissner, Vanessa Rousseau, Agnès Sommet, Pierre Payoux, Pierre Gantet, Amel Drif, Hélène Catalá, Claire Thalamas, Christine Tranchant, Franck Durif, Ana Marques, Alexandre Eusebio, Luc Defebvre, Jean‐Christophe Corvol, Stéphane Thobois, Anthime Flaus, Anne‐Gaelle Corbille, Solène Frismand, Beverley Patterson, Alexandra Foubert‐Samier, Anne Pavy‐Le Traon, Germain Arribarat, Patrice Péran, Olivier Rascol, for the ASPIRE Study Group   +26 more
wiley   +1 more source

Microstructure white matter changes and serum GFAP among different phenotypes of multiple sclerosis [PDF]

Romanian Journal of Neurology
Background. Multiple sclerosis (MS) is an autoimmune disease that targets the central nervous system (CNS). A patient’s degree of demyelination and axonal degeneration can only be roughly estimated based on clinical symptoms, neurochemical analysis or ...
Elsayed Orief, Samer Salama, Mohamed Elkhateeb, Ahmad El-Morsy   +3 more
doaj   +1 more source

Bioimaging of sense organs and the central nervous system in extant fishes and reptiles in situ: A review

The Anatomical Record, EarlyView.
Bioimaging of the sense organs and brain of fishes and reptiles. Left panel: 3D reconstruction of the head and brain of the deep‐sea viperfish Chauliodus sloani following diceCT. Right panel: A 3D reconstruction of a 70‐day‐old embryo head of the bearded dragon Pogona vitticeps following diceCT, showing the position of the segmented brain within the ...
Shaun P. Collin, Kara E. Yopak, Jenna M. Crowe‐Riddell, Victoria Camilieri‐Asch, Caroline C. Kerr, Hope Robins, Myoung Hoon Ha, Annalise Ceddia, Travis L. Dutka, Lucille Chapuis   +9 more
wiley   +1 more source

The Role of Resilience in Coping with Negative Parental Behaviour

Acta Educationis Generalis, 2019
Introduction: Negative parental behaviour is among the significant risk factors that can have a negative impact on an individual’s development. In certain contexts, when appropriate protective factors are available, individuals deal with adversity better
Barnová Silvia, Tamášová Viola, Krásna Slávka   +2 more
doaj   +1 more source

The Influence of Sports Leisure Activities on the Level of Moral Competence of High School Students

Acta Educationis Generalis, 2022
Introduction: In the relationship between sports morality and the morality of everyday life, there are no relevant studies and researches to clearly demonstrate the direct connections between sports and moral behaviour.
Lukáč Pavol, Tamášová Viola
doaj   +1 more source