Results 81 to 90 of about 48,188 (262)

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Alterations of White Matter Connectivity in Adults with Essential Hypertension

International Journal of General Medicine
Weijie Chen,1,2,* Simin Deng,3,* Huali Jiang,2,* Heng Li,2 Yu Zhao,2 Yiqiang Yuan4 1Department of Cardiology, The Second School of Clinical Medicine, Southern Medical University, Guangdong, People’s Republic of China; 2Department of ...
Chen W, Deng S, Jiang H, Li H, Zhao Y, Yuan Y   +5 more
doaj  

Relationship Between Mean Kärger Model Water Exchange Rate and Intercellular Water Transition Rate

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To derive a quantitative relationship between the mean Kärger model (KM) water exchange rate and the mean intercellular water transition rate applicable to brain and other complex biological tissues. Theory and Methods The mean KM water exchange rate applies to any KM, accommodates an arbitrary number of compartments, and can be ...
Jens H. Jensen, Hunter G. Moss, Thorsten Feiweier, Andreana Benitez   +3 more
wiley   +1 more source

Whole‐Brain Diffusion MRI at 7T With Universal Multiband GRAPE pTx Pulses

Magnetic Resonance in Medicine, EarlyView.
Purpose To improve signal strength and homogeneity of whole‐brain diffusion‐weighted imaging (DWI) at 7T. Methods Universal multiband excitation and refocusing pulses were optimized with the gradient ascent pulse engineering (GRAPE) algorithm across a database of B1+$$ {B}_1^{+} $$ and B0$$ {B}_0 $$ maps obtained from 20 subjects.
Marten Laufenberg, Daniel Löwen, Mónica Ferreira, Nicolas Boulant, Jennifer Faber, Tony Stöcker   +5 more
wiley   +1 more source

Simplified Anisotropic IVIM Using Spherical Means and an Application in the Placenta

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To reduce the complexity associated with anisotropic IVIM modeling, we derived two simplified diffusion MRI models that map the apparent diffusivity, relative proportions, and anisotropy of perfusion‐ and diffusion‐related signal components and demonstrated them in placenta scans.
Paddy J. Slator, Luke Pleva, Alexandra Crawford, Lucy Higgins, Edward Johnstone, Alexander E. P. Heazell, Daniel C. Alexander, Josephine H. Naish, Kate Duhig   +8 more
wiley   +1 more source

DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study. [PDF]

Hum Brain Mapp
A higher DTI‐derived ALPS index relates cross‐sectionally to both quantitative and visual measures of SVD and is associated with short‐term amyloid‐β accumulation in cognitively normal older adults. Also, greater amyloid burden and choroid plexus volume are associated with a more rapid deterioration in global cognition and processing speed.
Azizi N, Borooghani H, Kiani I, Gharaylou Z, Seyedi D, Firouznia K, Kolahi S.   +6 more
europepmc   +2 more sources

Cross‐Platform Demonstration of an Autonomous MRI Field Camera

Magnetic Resonance in Medicine, EarlyView.
Purpose Recent work has proposed self‐synchronization, self‐calibration, and means of sequence parsing to enhance the versatility of field cameras. The purpose of this paper is to expand this approach to more complex sequences and verify feasibility across distinct scanner platforms.
Oskar Björkqvist, Klaas P. Pruessmann
wiley   +1 more source

Strain Rate Angle Distribution as an Indicator of Post‐Infarct Myocardial Remodeling: Proof‐of‐Concept of a Novel Application of the MRI Derived Strain Rate Tensor Field

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Left ventricular (LV) strain is an early indicator of myocardial dysfunction. However, conventional strain metrics do not fully account for the multidirectional nature of myocardial deformation. The strain rate tensor, derived from velocity‐encoded MRI, represents the time‐resolved magnitude and direction of strain rate without the ...
Lasse Totland, Bård A. Bendiksen, Einar S. Nordén, Ida Marie Hauge‐Iversen, Kaja Knudsen Bergo, Lili Zhang, Ivar Sjaastad, Emil K. S. Espe   +7 more
wiley   +1 more source

Artificial intelligence, equity, and pediatric neurodevelopmental disorders: A scoping review of clinical practice applications

Pediatric Investigation, EarlyView.
Artificial intelligence (AI) is being explored to support diagnosis and care for pediatric neurodevelopmental disorders, yet most tools remain in early stages of development. This scoping review identifies limited external validation, narrow population representation, and sparse equity considerations, underscoring the need for inclusive, clinically ...
Florida Uzoaru, Obinna O. Oleribe, Ucheoma Nwaozuru, Parichart Sabado   +3 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source