Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer +11 more
wiley +1 more source
Successful Treatment of Long-Standing Dermatillomania With Sertraline in a Rural Mexican Patient: A Case Report and Literature Review. [PDF]
CureusCid-Puente R +3 more
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ADVANCED DTM GENERATION FROM VERY HIGH RESOLUTION SATELLITE STEREO IMAGES [PDF]
, 2015 Roland Perko +3 more
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Targeting the Spliceosomal Protein USP39 Through Allosteric Ligands and PROTAC‐Induced Degradation
Angewandte Chemie International Edition, Volume 65, Issue 5, 28 January 2026.Proteolysis‐targeting chimeras (PROTACs) enable degradation of proteins previously considered undruggable by harnessing the cellular ubiquitin–proteasome system. In this study, Schäfer et al. identify thiazole‐based small molecules that allosterically bind the zinc finger domain of ubiquitin‐specific protease 39 (USP39), a non‐enzymatic scaffold ...
Daniel Schäfer +11 more
wiley +1 more source
New modes of spinal cord stimulation for pain syndromes - Similar yet different approaches to improving outcomes. [PDF]
Indian J AnaesthZeng Y, Bhatia A.
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Genetic diversity and agromorphological characterization of Fenugreek (Trigonella foenum-graecum L.) germplasm provides insight for breeding and crop improvement. [PDF]
Sci RepMeena VS +5 more
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Efeitos da cirurgia ortognática bimaxilar em pacientes com e sem dtm muscular : estudo retrospectivo
, 2021 Bibiana Dalsasso Velasques
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Sind i‐Motiv‐Strukturen in DNA kompatibel mit Cytosin–Ag(I)–Cytosin‐Basenpaaren?
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Ein i‐Motiv/Duplex‐Konjugat wurde hinsichtlich seiner Fähigkeit untersucht, die Protonen der hemiprotonierten C:CH+‐Basenpaare durch AgI‐Ionen zu ersetzen, um C–AgI–C‐Basenpaare zu bilden. Interessanterweise wird nur ein einziges solches Basenpaar gebildet, bevor sich das Oligonukleotid in eine Duplexstruktur umlagert.
Victoria Seiffert +8 more
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Freqüência de relatos de parafunções nos subgrupos diagnósticos de DTM de acordo com os critérios diagnósticos para pesquisa em disfunções temporomandibulares (RDC/TMD) [PDF]
, 2008 Raquel Stumpf Branco +3 more
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