Results 61 to 70 of about 4,798,027 (263)

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Metabolic Reprogramming in Glioblastoma Stem Cells Promotes Radiation Resistance Through a H3K18la/USP30/MBOAT2 Axis

Advanced Science, EarlyView.
LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao, Wei Gu, Yimin Ren, Chenfei Lu, Wanzhi Cai, Junnan Lu, Zhongyuan Bao, Yanan Zhou, Rong Li, Ke Jin, Chao Chen, Hongxiang Wang, Lei Xu, Juxiang Chen   +13 more
wiley   +1 more source

Effects of transformer’s turn ratio mismatch towards the performance of dual active bridge converter [PDF]

, 2018
This paper presents the study of the effect of transformer’s turn ratio mismatch on the performance of dual active bridge (DAB) converter. DAB converter was part of the components of a solid state transformer (SST) where it provides galvanic isolation as
Hamdan, Daniyal, Nur Huda, Ramlan, Tiong, Meng Chung, Suliana, Ab Ghani   +3 more
core   +2 more sources

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

A Novel Structure of Variable Inductance High-Frequency Transformer for Power Level Enhancement in Dual-Active-Bridge Converters

Energies
This study presents a novel structure proposal of a variable inductance high-frequency transformer for enhancement power level of a dual-active-bridge (DAB) converter.
Cheol-Woong Choi, Jae-Sub Ko, Keun-Yong Yoon, Yong-Un Park, Yun-Soo Kang, Dae-Kyong Kim   +5 more
doaj   +1 more source

Analytical modelling and power density optimisation of a single phase dual active bridge for aircraft application

The Journal of Engineering, 2019
A design procedure for the dual active bridge (DAB) converter is presented, which aims to optimised power density and computational effort. When designing a DAB, the selection of circuit design parameters such as switching frequency, leakage inductance ...
Niklas Fritz, Mohamed Rashed, Serhiy Bozhko, Fabrizio Cuomo, Pat Wheeler   +4 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Discrete Inductor Free Phase Shifted Dual Active Bridge Converter for EV DC Fast Charging Application

This paper studies a compact dual active bridge (DAB) converter by adopting a latest high-frequency transformer (HFT). Traditional DAB converter requires the discrete inductor to perform the energy transfer operation, which increases the overall size ...
Subhani, N, Yao, W, Lu, J, Zhu, Y
core   +1 more source

Force‐Electric Nanotentacles of Tantalum Implant Accelerate Cellular Energy Metabolism/Crosstalk for Immunomodulation‐Vascularized Bone Integration

Advanced Science, EarlyView.
A biomimetic force‐electric nanotentacle‐enabled tantalum (Ta) implant with surface‐nanostructured LiTaO3 (n‐LiTaO3) was first developed via laser nanofabrication combined with Li+‐induced in situ reaction, enabling the transduction of ultrasound into bioelectrical cues.
Taixing Zhang, Ke Ma, Kangqing Zuo, Pandong Lin, Tailong Zhang, Rongliang Ding, Linbo Zhang, Aonan Li, Yinchuan Wang, Yanling Huang, Jichao Feng, Guiyong Xiao, Yupeng Lu, Bing Han, Zhiqiang Wang, Ningbo Li   +15 more
wiley   +1 more source

T-Type-Based Dual-Active-Bridge DC-DC Converter With Voltage Balancing Capability for Bipolar DC Distribution System

IEEE Access
A dual-active-bridge (DAB) converter has been widely used to construct the dc bus voltage of a dc distribution system. However, in the case of a bipolar dc system, conventional DAB converters fail to regulate the bipolar dc bus voltage levels due to the ...
Jun Young Lee, Jun-Suk Lee, Jee-Hoon Jung   +2 more
doaj   +1 more source