Results 41 to 50 of about 748 (219)
FEBS Open Bio, EarlyView.Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar +4 more
wiley +1 more source
Journal of Manufacturing and Materials Processing, 2019 It is well known that stress-induced phase transformation in dual-phase steel leads to the degradation of bulk corrosion resistance properties. Predicting this behaviour in high carbon steel is imperative for designing this grade of steel for more ...
Wilson Handoko +3 more
doaj +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Effect of Quenching in Dual-phase Region on Microstructure and Mechanical Properties of 7Ni Steel
Cailiao gongcheng, 2018 The influence of quenching temperature and holding time in dual-phase region on microstructure and mechanical properties of 7Ni steel was studied by X-ray diffractometer, scanning electron microscopy and thermal dilatometer.
XU Li-xiong, WU Hui-bin, MOU Dan
doaj +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source
Tailoring dual-phase steel properties through controlled temperature and holding time during heat treatment [PDF]
MATEC Web of ConferencesThis study investigates the effect of controlled temperature and holding time on the microstructure and properties of DP600 dual-phase steel. Low-carbon steel (0.3 wt%C) was heat-treated at 850°C with holding times of 20, 40, 60, and 80 minutes, followed
Olorundaisi Emmanuel, Olubambi Peter A.
doaj +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Determining the influence of material solutions on durability and tare mass of light car trailers [PDF]
Transport Problems, 2010 The modern light trailers constructions are expected to have considerable safety level, guaranteed by the high construction durability as well as possible low mass.
Maciej BOLDYS
doaj
Metallurgical Effects of Niobium in Dual Phase Steel
Metals, 2020 Dual phase (DP) steels are widely applied in today’s automotive body design. The favorable combination of strength and ductility in such steels is in first place related to the share of ferrite and martensite.
Hardy Mohrbacher +4 more
doaj +1 more source