Results 101 to 110 of about 40,110 (297)

A modified cysteinyl-labeling assay reveals reversible oxidation of classical and dual specificity phosphatases in angiomyolipoma cells [PDF]

, 2008
The production of reactive oxygen species (ROS) exerts an additional tier of control over tyrosine phosphorylation-dependent signal transduction by transiently inhibiting the catalytic activity of specific protein tyrosine phosphatases (PTPs). Hence, the
B. Boivin, S. Zhang, J. L. Arbiser, Z.-Y. Zhang, N. K. Tonks, Tonks, Finkel, Rhee, Barford, Denu, Salmeen, Rhee, Lou, Barrett, Sundaresan, Meng, Meng, Singh, Lee, Kamata, Sun   +20 more
core   +1 more source

Data from Dual Specificity Phosphatase 1/CL100 Is a Direct Transcriptional Target of E2F-1 in the Apoptotic Response to Oxidative Stress

, 2023
Jianli Wang, David P. Yin, Yuxin Liu, Richard Baer, Yuxin Yin   +4 more
openalex   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Role of dual specificity phosphatase 1 in influencing inflammatory pathways in macrophages modulated by Borrelia burgdorferi lipoproteins

Frontiers in Immunology
Borrelia burgdorferi (Bb), the spirochetal agent of Lyme disease, has a large array of lipoproteins that play a significant role in mediating host-pathogen interactions within ticks and vertebrates.
Venkatesh Kumaresan, Susanta Pahari, Chiung-Yu Hung, Brian P. Hermann, Larry S. Schlesinger, J. Seshu   +5 more
doaj   +1 more source

Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression

Cell Communication and Signaling, 2012
Protein-tyrosine phosphatases (PTPs) are important regulators of cellular signaling and changes in PTP activity can contribute to cell transformation. Little is known about the role of PTPs in Acute Myeloid Leukemia (AML).
Arora Deepika, Köthe Susanne, van den Eijnden Monique, van Huijsduijnen Rob, Heidel Florian, Fischer Thomas, Scholl Sebastian, Tölle Benjamin, Böhmer Sylvia-Annette, Lennartsson Johan, Isken Fabienne, Müller-Tidow Carsten, Böhmer Frank-D   +12 more
doaj   +1 more source

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]

, 2014
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Alessi, Dario R., Bago, Ruzica, Cross, Darren, Davies, Paul, Ganley, Ian G., Malik, Nazma, Munson, Michael J., Prescott, Alan R., Shpiro, Natalia, Sommer, Eeva, Ward, Richard   +10 more
core   +3 more sources

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

The Putative Protein Phosphatase MoYvh1 Functions Upstream of MoPdeH to Regulate the Development and Pathogenicity in Magnaporthe oryzae

Molecular Plant-Microbe Interactions, 2016
Protein phosphatases are critical regulators in eukaryotic cells. For example, the budding yeast Saccharomyces cerevisiae dual specificity protein phosphatase (DSP) ScYvh1 regulates growth, sporulation, and glycogen accumulation. Despite such importance,
Xinyu Liu, Bin Qian, Chuyun Gao, Shuohan Huang, Yongchao Cai, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang   +8 more
doaj   +1 more source

Expression of dual-specificity phosphatases in TGFß1-induced EMT in SKOV3 cells. [PDF]

Turk J Med Sci, 2023
Güler S, Yalçın A.
europepmc   +1 more source

The role of bacterial protein tyrosine phosphatases in the regulation of the biosynthesis of secreted polysaccharides [PDF]

, 2014
SIGNIFICANCE: Tyrosine phosphorylation and associated protein tyrosine phosphatases are gaining prominence as critical mechanisms in the regulation of fundamental processes in a wide variety of bacteria.
Morona, R., Standish, A.
core   +1 more source