Results 1 to 10 of about 134,984 (294)

Methylation of dual-specificity phosphatase 4 controls cell differentiation [PDF]

Cell Reports, 2021
Summary: Mitogen-activated protein kinases (MAPKs) are inactivated by dual-specificity phosphatases (DUSPs), the activities of which are tightly regulated during cell differentiation. Using knockdown screening and single-cell transcriptional analysis, we
Hairui Su, Ming Jiang, Chamara Senevirathne, Srinivas Aluri, Tuo Zhang, Han Guo, Juliana Xavier-Ferrucio, Shuiling Jin, Ngoc-Tung Tran, Szu-Mam Liu, Chiao-Wang Sun, Yongxia Zhu, Qing Zhao, Yuling Chen, LouAnn Cable, Yudao Shen, Jing Liu, Cheng-Kui Qu, Xiaosi Han, Christopher A. Klug, Ravi Bhatia, Yabing Chen, Stephen D. Nimer, Y. George Zheng, Camelia Iancu-Rubin, Jian Jin, Haiteng Deng, Diane S. Krause, Jenny Xiang, Amit Verma, Minkui Luo, Xinyang Zhao   +31 more
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Dual-Specificity Phosphatase 11 Is a Prognostic Biomarker of Intrahepatic Cholangiocarcinoma [PDF]

Frontiers in Oncology, 2021
BackgroundCholangiocarcinoma (CCA), including intrahepatic (iCCA), perihilar (pCCA), and distal (dCCA) CCA, is a highly aggressive malignancy originating from bile duct.
Lin Xu, Peng Wang, Wei Zhang, Weiran Li, Tao Liu, Xu Che, Xu Che   +6 more
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Dual‐Specificity Phosphatase 26 Protects Against Cardiac Hypertrophy Through TAK1 [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Heart pathological hypertrophy has been recognized as a predisposing risk factor for heart failure and arrhythmia. DUSP (dual‐specificity phosphatase) 26 is a member of the DUSP family of proteins, which has a significant effect on ...
Jing Zhao, Xiaoli Jiang, Jinhua Liu, Ping Ye, Lang Jiang, Manhua Chen, Jiahong Xia   +6 more
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ALV-miRNA-p19-01 Promotes Viral Replication via Targeting Dual Specificity Phosphatase 6 [PDF]

Viruses, 2022
MicroRNAs (miRNAs) are a group of regulatory noncoding RNAs, serving as major regulators with a sequence-specific manner in multifarious biological processes.
Yiming Yan, Sheng Chen, Liqin Liao, Shuang Gao, Yanling Pang, Xinheng Zhang, Huanmin Zhang, Qingmei Xie   +7 more
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Dual specificity phosphatase 1 attenuates inflammation-induced cardiomyopathy by improving mitophagy and mitochondrial metabolism [PDF]

Molecular Metabolism, 2022
Objectives: Dual specificity phosphatase 1 (DUSP1) is regarded as an anti-inflammatory factor in cardiovascular disorders. Mitophagy removes damaged mitochondria and thus promotes mitochondrial regeneration.
Ying Tan, Yue Zhang, Jing He, Feng Wu, Di Wu, Nengxian Shi, Weifeng Liu, Ziying Li, Wenqian Liu, Hao Zhou, Wenting Chen   +10 more
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Dual specificity phosphatase 1 as a non-invasive circulating biomarker candidate in preeclampsia [PDF]

Frontiers in Endocrinology
IntroductionPreeclampsia (PE) is a multisystem pregnancy complication. Factors pointing to a placental origin are the development of the pathology only during pregnancy, and its disappearance in the post-partum period.MethodsHere, we aim to identify ...
Jonatane Andrieu, Agathe Donet, Agathe Donet, Jean-François Cocallemen, Guillaume Charbonnier, Noémie Resseguier, Julien Paganini, Jean-Louis Mège, Jean-Louis Mège, Soraya Mezouar, Soraya Mezouar, Florence Bretelle, Florence Bretelle   +12 more
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Proteomic Signaling of Dual-Specificity Phosphatase 4 (DUSP4) in Alzheimer’s Disease [PDF]

Biomolecules
DUSP4 is a member of the DUSP (dual-specificity phosphatase) subfamily that is selective to the mitogen-activated protein kinases (MAPK) and has been implicated in a range of biological processes and functions in Alzheimer’s disease (AD).
Erming Wang, Allen L. Pan, Pritha Bagchi, Srikant Rangaraju, Nicholas T. Seyfried, Michelle E. Ehrlich, Stephen R. Salton, Bin Zhang   +7 more
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Prognostic Significance of Dual-Specificity Phosphatase 23 Expression in Acute Myeloid Leukemia [PDF]

Journal of Blood Medicine
Xi Liu,1,2 Haihui Zhuang,1,2 Fenglin Li,1,2 Ying Lu,1,2 Renzhi Pei1,2 1Department of Hematology, The Affiliated People’s Hospital of Ningbo University, Ningbo, People’s Republic of China; 2Institute of Hematology, Ningbo University, Ningbo, People’s ...
Liu X, Zhuang H, Li F, Lu Y, Pei R
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Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase [PDF]

Nature Communications
Dual-specificity mitogen-activated protein kinase (MAPK) phosphatases (MKPs) directly dephosphorylate and inactivate the MAPKs. Although the catalytic mechanism of dephosphorylation of the MAPKs by the MKPs is established, a complete molecular picture of
Erin Skeens, Federica Maschietto, Ramu Manjula, Shanelle Shillingford, James Murphy, Elias J. Lolis, Victor S. Batista, Anton M. Bennett, George P. Lisi   +8 more
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Dual-Specificity Phosphatase 14 Regulates Zebrafish Hair Cell Formation Through Activation of p38 Signaling Pathway [PDF]

Frontiers in Cellular Neuroscience, 2022
Most cases of acquired hearing loss are due to degeneration and subsequent loss of cochlear hair cells. Whereas mammalian hair cells are not replaced when lost, in zebrafish, they constantly renew and regenerate after injury.
Guanyun Wei, Xu Zhang, Xu Zhang, Chengyun Cai, Jiajing Sheng, Mengting Xu, Cheng Wang, Qiuxiang Gu, Chao Guo, Fangyi Chen, Fangyi Chen, Dong Liu, Fuping Qian   +12 more
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