Results 1 to 10 of about 40,054 (307)

Systemic inflammation suppresses spinal respiratory motor plasticity via mechanisms that require serine/threonine protein phosphatase activity

Journal of Neuroinflammation, 2021
Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli, Yasin B. Seven, Raphael R. Perim, Gordon S. Mitchell   +3 more
doaj   +1 more source

Role of extracellular signal-regulated kinase 1/2 signaling underlying cardiac hypertrophy

Cardiology Journal, 2021
Cardiac hypertrophy is the result of increased myocardial cell size responding to an increased workload and developmental signals. These extrinsic and intrinsic stimuli as key drivers of cardiac hypertrophy have spurred efforts to target their associated
Zhi-Peng Yan, Jie-Ting Li, Ni Zeng, Guo-Xin Ni   +3 more
doaj   +1 more source

Induction of Ptp2 and Cmp2 protein phosphatases is crucial for the adaptive response to ER stress in Saccharomyces cerevisiae [PDF]

, 2018
Expression control of the protein phosphatase is critically involved in crosstalk and feedback of the cellular signaling. In the budding yeast ER stress response, multiple signaling pathways are activated and play key roles in adaptive reactions. However,
Irie Kenji, Mizuno Tomoaki, Nakamura Meyu, 入江 賢児   +3 more
core   +3 more sources

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Alavi A, Barbara Walzog, Bennett AM, Brooks PC, Chan RJ, Chang F, Chen J, Christian Plank, Crompton T, Cunnick JM, Distler JH, Florian Krötz, Frisch SM, Hadari YR, Hae-Young Sohn, Hanna Mannell, Hu Y, Huang P, Ivins Zito C, Kontaridis MI, Krotz F, Krotz F, Krotz F, Krotz F, Leopold Groesser, Munoz-Chapuli R, Neel BG, Neel BG, Nicole Hellwig, Noguchi T, Nor JE, Ong SH, O’Brien CD, Papetti M, Plank C, Qi JH, Qi JH, Qu CK, Ren Y, Saxton TM, Shi ZQ, Slater EP, Tang TL, Thakker GD, Tomanek RJ, Torsten Gloe, Ulrich Pohl, Wu CJ, Yart A, Zhang SQ, Zhang SQ   +50 more
core   +1 more source

Protein phosphatase AP2C1 negatively regulates basal resistance and defense responses to Pseudomonas syringae [PDF]

, 2017
Mitogen-activated protein kinases (MAPKs) mediate plant immune responses to pathogenic bacteria. However, less is known about the cell autonomous negative regulatory mechanism controlling basal plant immunity. We report the biological role of Arabidopsis
Alois Schweighofer, Bernd Mueller-Roeber, Cheng, Cyril Zipfel, Dempsey, Felix Mauch, Freddy Boutrot, Han, Hruz, Irute Meskiene, Justinas Simulis, Justyna Boniecka, Kotryna Kvederaviciute, Lassowskat, Michael Stumpe, Rasmussen, Salma Balazadeh, Volodymyr Shubchynskyy   +17 more
core   +1 more source

P2X7 Nucleotide and EGF Receptors Exert Dual Modulation of the Dual-Specificity Phosphatase 6 (MKP-3) in Granule Neurons and Astrocytes, Contributing to Negative Feedback on ERK Signaling

Frontiers in Molecular Neuroscience, 2018
Extracellular signal-regulated kinases 1 and 2 (ERK1/2) play a central role in the intracellular signaling of P2X7 nucleotide receptors in neurons and glial cells.
Mª José Queipo, Juan C. Gil-Redondo, Verónica Morente, Felipe Ortega, Mª Teresa Miras-Portugal, Esmerilda G. Delicado, Raquel Pérez-Sen   +6 more
doaj   +1 more source

RNA-Binding Protein Rnc1 Regulates Cell Length at Division and Acute Stress Response in Fission Yeast through Negative Feedback Modulation of the Stress-Activated Mitogen-Activated Protein Kinase Pathway

mBio, 2020
RNA-binding proteins (RBPs) play a major role during control of mRNA localization, stability, and translation and are central to most cellular processes.
Francisco Prieto-Ruiz, Jero Vicente-Soler, Alejandro Franco, Elisa Gómez-Gil, Marta Sánchez-Marinas, Beatriz Vázquez-Marín, Rosa Aligué, Marisa Madrid, Sergio Moreno, Teresa Soto, José Cansado   +10 more
doaj   +1 more source

Opposing Roles for the α Isoform of the Catalytic Subunit of Protein Phosphatase 1 in Inside–Out and Outside–In Integrin Signaling in Murine Platelets

Cells, 2023
Platelet activation during hemostasis and thrombosis is facilitated by agonist-induced inside–out and integrin αIIbβ3-initiated outside–in signaling via protein kinases and phosphatases. Pharmacological inhibitor studies suggest that the serine/threonine
Tanvir Khatlani, Subhashree Pradhan, Kimberly Langlois, Deepika Subramanyam, Rolando E. Rumbaut, K. Vinod Vijayan   +5 more
doaj   +1 more source

MAPK phosphatase AP2C3 induces ectopic proliferation of epidermal cells leading to stomata development in Arabidopsis.

PLoS ONE, 2010
In plant post-embryonic epidermis mitogen-activated protein kinase (MAPK) signaling promotes differentiation of pavement cells and inhibits initiation of stomata. Stomata are cells specialized to modulate gas exchange and water loss.
Julija Umbrasaite, Alois Schweighofer, Vaiva Kazanaviciute, Zoltan Magyar, Zahra Ayatollahi, Verena Unterwurzacher, Chonnanit Choopayak, Justyna Boniecka, James A H Murray, Laszlo Bogre, Irute Meskiene   +10 more
doaj   +1 more source

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response. [PDF]

, 2020
Abiotic stresses, including drought and salinity, trigger a complex osmotic-stress and abscisic acid (ABA) signal transduction network. The core ABA signalling components are snf1-related protein kinase2s (SnRK2s), which are activated by ABA-triggered ...
Ceciliato, Paulo HO, Dubeaux, Guillaume, Ge, Chennan, Hauser, Felix, Hsu, Po-Kai, Munemasa, Shintaro, Schroeder, Julian I, Takahashi, Yohei, Zhang, Jingbo, Zhang, Li, Zhao, Yunde   +10 more
core