Results 31 to 40 of about 40,054 (307)

Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2 [PDF]

Journal of Biological Chemistry, 1999
The mitogen-activated protein kinase phosphatase 3 (MKP3)-catalyzed hydrolysis of aryl phosphates in the absence and presence of extracellular signal-regulated kinase 2 (ERK2) was investigated in order to provide insights into the molecular basis of the ERK2-induced MKP3 activation.
B, Zhou, Z Y, Zhang
openaire   +2 more sources

N6-Methyladenosine and Reader Protein YTHDF2 Enhance the Innate Immune Response by Mediating DUSP1 mRNA Degradation and Activating Mitogen-Activated Protein Kinases during Bacterial and Viral Infections

mBio, 2023
Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections.
Jian Feng, Wen Meng, Luping Chen, Xinquan Zhang, Ashley Markazi, Weiming Yuan, Yufei Huang, Shou-Jiang Gao   +7 more
doaj   +1 more source

Research advances of dual-specificity phosphatases in kidney disease

Linchuang shenzangbing zazhi, 2021
Belonging to the family of protein tyrosine phosphatases,DUSPs（dual-specificity phosphatases）can dephosphorylate both serine/threonine and tyrosine residues concurrently.In recent years,with the in-depth study of DUSPs,they have been implicated as major ...
杜宇, 章波, 赵景宏
doaj  

Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. [PDF]

PLoS ONE, 2012
Fibroblast growth factor receptor substrate 2 (FRS2α) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases.
Ana Tomasovic, Stephanie Traub, Ritva Tikkanen   +2 more
doaj   +1 more source

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen [PDF]

, 2017
The authors thank E. Veal for intellectual input. This work was funded by the UK Biotechnology and Biological Research Council [J.Q. BB/K016393/1; A.J.P.B.
Brown, Alistair J P, Day, Alison M, Herrero-de-Dios, Carmen M., MacCallum, Donna M, Quinn, Janet   +4 more
core   +2 more sources

Central Roles and Regulatory Mechanisms of Dual-Specificity MAPK Phosphatases in Developmental and Stress Signaling

Frontiers in Plant Science, 2018
Mitogen-Activated Protein Kinase (MAPK) cascades are conserved signaling modules that integrate multiple signaling pathways. One level of control on the activity of MAPKs is through their negative regulators, MAPK phosphatases (MKPs).
Lingyan Jiang, Lingyan Jiang, Yinhua Chen, Yinhua Chen, Lijuan Luo, Lijuan Luo, Scott C. Peck, Scott C. Peck, Scott C. Peck   +8 more
doaj   +1 more source

Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages. [PDF]

PLoS ONE, 2013
Protein tyrosine phosphatases play key roles in a diverse range of cellular processes such as differentiation, cell proliferation, apoptosis, immunological signaling, and cytoskeletal function.
Huiyun Seo, In-Seon Lee, Jae Eun Park, Sung Goo Park, Do Hee Lee, Byoung Chul Park, Sayeon Cho   +6 more
doaj   +1 more source

Approximations and their consequences for dynamic modelling of signal transduction pathways [PDF]

, 2007
Signal transduction is the process by which the cell converts one kind of signal or stimulus into another. This involves a sequence of biochemical reactions, carried out by proteins.
Asthagiri, Atkins, Blüthgen, Briggs, Brightmann, Chen, Cho, Cornish-Bowden, Crampin, De Jong, Downward, Eissing, Eric Bullinger, Fell, Ferrell, Ferrell, Ferrell, Fowler, Goldbeter, Goldbeter, Hatakeyama, Heinrich, Heinrich, Huang, Johann Rohwer, Kholodenko, Kholodenko, Laurent, Lewis, Llórens, Markevich, Mathews, Michaelis, Novak, Olaf Wolkenhauer, Rubinow, Schilling, Schnell, Schoeberl, Segel, Swameye, Thomas Millat, Timmer, Tyson, Tzafriri, Winfree, Wolkenhauer, Wolkenhauer, Wolkenhauer, Yeung   +49 more
core   +1 more source

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]

, 2008
We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Abraham, Abraham, Angelika M. Vollmar, Bagowski, Bokemeyer, Bokemeyer, Castro-Caldas, Clark, Clark, Dickinson, Fürst, Fürst, Fürst, Hafezi-Moghadam, Iuchi, Karst, Kiemer, Kiemer, Kim, Koukouritaki, Kwak, Lang, Limbourg, Liu, Liu, Long, Pelaia, Qiu, Robert Fürst, Sanchez-Tillo, Schaaf, Simoncini, Song, Stahn, Stefan Zahler, Sun, Zahler   +36 more
core   +1 more source

A Novel Mitogen-activated Protein Kinase Phosphatase. STRUCTURE, EXPRESSION, AND REGULATION [PDF]

Journal of Biological Chemistry, 1995
Mitogen-activated protein (MAP) kinase lies at the convergence of various extracellular ligand-mediated signaling pathways. It is activated by the dual-specificity kinase, MAP kinase kinase or MEK. MAP kinase inactivation is mediated by dephosphorylation via specific MAP kinase phosphatases (MKPs).
A, Misra-Press, C S, Rim, H, Yao, M S, Roberson, P J, Stork   +4 more
openaire   +2 more sources