Results 11 to 20 of about 40,054 (307)
Mitogen-Activated Protein Kinase Phosphatases: No Longer Undruggable? [PDF]
Annu Rev Pharmacol Toxicol, 2023 Phosphatases and kinases maintain an equilibrium of dephosphorylated and phosphorylated proteins, respectively, that are required for critical cellular functions. Imbalance in this equilibrium or irregularity in their function causes unfavorable cellular effects that have been implicated in the development of numerous diseases.
Shillingford SR, Bennett AM.
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Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2. [PDF]
PLoS ONE, 2014 The mitogen-activation protein kinase ERK2 is tightly regulated by multiple phosphatases, including those of the kinase interaction motif (KIM) PTP family (STEP, PTPSL and HePTP).
Dana M Francis +4 more
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Mitogen-activated protein kinases and mitogen kinase phosphatase 1: a critical interplay in macrophage biology [PDF]
Frontiers in Molecular Biosciences, 2016 Macrophages are necessary in multiple processes during the immune response or inflammation. This review emphasizes the critical role of the mitogen-activated protein kinases (MAPKs) and mitogen kinase phosphatase-1 (MKP-1) in the functional activities of
Celada Cotarelo, Antonio +4 more
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Mitogen activated protein kinase phosphatases and cancer. [PDF]
Cancer Biol Ther, 2010 Deregulation of cell signaling is a vital part of cancer development. The mitogen activated protein kinase (MAPK) family is involved in regulating both cell growth and cell death. This family of kinases is negatively regulated by mitogen activated protein kinase phosphatases (MKPs).
Haagenson KK, Wu GS.
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Emerging roles of PHLPP phosphatases in lung cancer
Frontiers in Oncology, 2023 Pleckstrin homologous domain leucine-rich repeating protein phosphatases (PHLPPs) were originally identified as protein kinase B (Akt) kinase hydrophobic motif specific phosphatases to maintain the cellular homeostasis.
Xinhang Xia +7 more
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Journal of Fungi, 2021 Protein phosphorylation cascades are universal in cell signaling. While kinome diversity allows specific phosphorylation events, relatively few phosphatases dephosphorylate key signaling proteins.
Rina Zuchman +2 more
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Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases. [PDF]
PLoS ONE, 2011 We earlier showed that 18β-glycyrrhetinic acid (GRA), a pentacyclic triterpenoid from licorice root, could completely cure visceral leishmaniasis in BALB/c mouse model.
Anindita Ukil +4 more
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Frontiers in Plant Science, 2022 Tyrosine-specific protein tyrosine phosphatases (Tyr-specific PTPases) are key signaling enzymes catalyzing the removal of the phosphate group from phosphorylated tyrosine residues on target proteins.
Valérie Nicolas-Francès +9 more
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EhMAPK, the mitogen-activated protein kinase from Entamoeba histolytica is associated with cell survival. [PDF]
PLoS ONE, 2010 Mitogen Activated Protein Kinases (MAPKs) are a class of serine/threonine kinases that regulate a number of different cellular activities including cell proliferation, differentiation, survival and even death. The pathogen Entamoeba histolytica possess a
Anupama Sardar Ghosh +3 more
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FEBS Open Bio, 2020 Phosphatidylinositol (3,4,5)‐trisphosphate (PI(3,4,5)P3) is required for protein kinase B (AKT) activation. The level of PI(3,4,5)P3 is constantly regulated through balanced synthesis by phosphoinositide 3‐kinase (PI3K) and degradation by ...
Abdelhalim Azzi
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