Results 51 to 60 of about 40,054 (307)

Diverse physiological functions for dual-specificity MAP kinase phosphatases [PDF]

, 2006
A structurally distinct subfamily of ten dual-specificity (Thr/Tyr) protein phosphatases is responsible for the regulated dephosphorylation and inactivation of mitogen-activated protein kinase (MAPK) family members in mammals.
Dickinson, Robin J, Keyse, Stephen M
core   +4 more sources

p63α and γ Induce TAU Phosphorylation in Cultured Mammalian Cells

Journal of Experimental Neuroscience, 2010
Here we show by western blotting that transcriptionally active isoforms of p63 (p63α and p63γ) induce the phosphorylation of human 2N4R tau at the tau-1/AT8 epitope in HEK293a cells; a phospho-epitope increased in Alzheimer's disease. Confocal microscopy
Claudie Hooper, Reem Soliman, Simon Lovestone, Richard Killick   +3 more
doaj   +1 more source

New Aspects of Neurotransmitter Release and Exocytosis: Dynamic and Differential Regulation of Synapsin I Phosphorylation by Acute Neuronal Excitation In Vivo

Journal of Pharmacological Sciences, 2003
: Synapsin I is a synaptic vesicle-associated protein that is phosphorylated at multiple sites by various protein kinases. It has been proposed to play an important role in the regulation of neurotransmitter release and the organization of cytoskeletal ...
Yoko Yamagata
doaj   +1 more source

Activation of AtMPK9 through autophosphorylation that makes it independent of the canonical MAPK cascades. [PDF]

, 2015
Mitogen activated protein kinases (MAPKs) are part of conserved signal transduction modules in eukaryotes that are typically organised into three-tiered kinase cascades.
Bogre L, Bánhegyi, Gábor, Darula, Zsuzsanna, Horváth V., Gábor, Kállai, Brigitta Margit, Medzihradszky F., Katalin, Mészáros, Tamás, Nagy, Szilvia Krisztina   +7 more
core   +1 more source

Manganese modulation of MAPK pathways: effects on upstream mitogen activated protein kinase kinases and mitogen activated kinase phosphatase‐1 in microglial cells [PDF]

Journal of Applied Toxicology, 2010
AbstractMultiple studies demonstrate that manganese (Mn) exposure potentiates inflammatory mediator output from activated glia; this increased output is associated with enhanced mitogen activated protein kinase (MAPK: p38, ERK and JNK) activity. We hypothesized that Mn activates MAPK by activating the kinases upstream of MAPK, i.e. MKK‐3/6, MKK‐1/2 and
Patrick L, Crittenden, Nikolay M, Filipov   +1 more
openaire   +2 more sources

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. [PDF]

, 2017
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Protein tyrosine phosphatases have received little attention in the study of SSc or fibrosis.
Bai, Yunpeng, Boin, Francesco, Bottini, Nunzio, Ceponis, Arnold, Chernitskiy, Vladimir, Cipriani, Paola, Di Benedetto, Paola, Giacomelli, Roberto, Jimenez, Sergio A, Kaestner, Klaus H, Kiosses, William B, Piera-Velazquez, Sonsoles, Sacchetti, Cristiano, Santelli, Eugenio, Stanford, Stephanie M, Zhang, Zhong-Yin   +15 more
core   +2 more sources

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Makhtar, Mokhairi, Neagu, Daniel, Ridley, Mick, Yang, Longzhi   +3 more
core   +2 more sources

The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes

Viruses, 2021
JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML).
Michael P. Wilczek, Francesca J. Armstrong, Remi P. Geohegan, Colleen L. Mayberry, Jeanne K. DuShane, Benjamin L. King, Melissa S. Maginnis   +6 more
doaj   +1 more source

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling [PDF]

, 2014
The renin angiotensin system (RAS) is integral to cardiovascular physiology, however, dysregulation of this system largely contributes to the pathophysiology of cardiovascular disease (CVD).
Akishita, Barroso, Booz, Bosnyak, Bosnyak, Brosnihan, Bruneval, Bryan, Calo, Campbell, Caroline Fattah, Castro, Chappell, Chappell, Chen, Christopher M. Loughrey, Clare A. McKinney, Clarke, Costa, Crackower, Cushman, De Mello, Dias-Peixoto, Domeier, Dong, Donoghue, Donoghue, Drummer, Faria-Silva, Ferreira, Ferreira, Ferreira, Ferreira, Flores-Munoz, Flores-Munoz, Fomovsky, Fraga-Silva, Fraga-Silva, Freeman, Galis, Gava, Gembardt, Gomes, Graeme Milligan, Grobe, Gusev, Hanke, Hannan, Harmer, Heitsch, Horiguchi, Horiuchi, Hunyady, Inaba, Iwata, Jackman, Jaiswal, Jarajapu, Kaminska, Kassiri, Katada, Kokkonen, Kramkowski, Langeveld, Lautner, Liao, Libby, Liu, Loot, Lovren, Masson, McCollum, Mehta, Mercure, Miura, Mogielnicki, Nakajima, Newby, Ng, Nouet, Ocaranza, Ocaranza, Ocaranza, Patel, Patel, Qi, Ray, Rice, Rodgers, Rodrigues-Machado, Ross, Rowe, Sampaio, Sampaio, Santos, Santos, Schultz Jel, Selvetella, Shah, Sheng-Long, Singh, Sluimer, Stegbauer, Strawn, Stuart A. Nicklin, Tallant, Tesanovic, Tipnis, Turner, Uekama, Varagic, Vickers, Vilas-Boas, Walters, Wang, Weber, West, Wiemer, Yamada, Yang, Zeng, Zhang, Zhao, Zhong   +123 more
core   +1 more source

Voltage-Gated T-Type Calcium Channel Modulation by Kinases and Phosphatases: The Old Ones, the New Ones, and the Missing Ones

Cells, 2023
Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis, and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate signaling pathways that control a broad range of physiological as well ...
Ankush Sharma, Ghazala Rahman, Julia Gorelik, Anamika Bhargava   +3 more
doaj   +1 more source