Dual-Specificity Phosphatases in Neuroblastoma Cell Growth and Differentiation. [PDF]
Int J Mol Sci, 2019 Dual-specificity phosphatases (DUSPs) are important regulators of neuronal cell growth and differentiation by targeting proteins essential to neuronal survival in signaling pathways, among which the MAP kinases (MAPKs) stand out.
Nunes-Xavier CE +5 more
europepmc +6 more sources
Dual-Specificity Phosphatases and Kidney Diseases [PDF]
Kidney Diseases, 2021 Background: Dual-specificity phosphatases (DUSPs) belong to the family of protein tyrosine phosphatases, which can dephosphorylate both serine/threonine and tyrosine residues.
Haiyang Li +4 more
doaj +2 more sources
Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance [PDF]
Scientific Reports, 2022 Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often associated with drug resistance.
Mithalesh K. Singh +4 more
doaj +2 more sources
Dual-specificity phosphatases 22-deficient T cells contribute to the pathogenesis of ankylosing spondylitis [PDF]
BMC Medicine, 2023 Background Dual-specificity phosphatases (DUSPs) can dephosphorylate both tyrosine and serine/threonine residues of their substrates and regulate T cell-mediated immunity and autoimmunity.
Ming-Han Chen +4 more
doaj +2 more sources
BCI, an inhibitor of the DUSP1 and DUSP6 dual specificity phosphatases, enhances P2X7 receptor expression in neuroblastoma cells [PDF]
Frontiers in Cell and Developmental Biology, 2022 P2X7 receptor (P2RX7) is expressed strongly by most human cancers, including neuroblastoma, where high levels of P2RX7 are correlated with a poor prognosis for patients.
María Benito-León +18 more
doaj +2 more sources
Phosphotyrosine Substrate Sequence Motifs for Dual Specificity Phosphatases. [PDF]
PLoS ONE, 2015 Protein tyrosine phosphatases dephosphorylate tyrosine residues of proteins, whereas, dual specificity phosphatases (DUSPs) are a subgroup of protein tyrosine phosphatases that dephosphorylate not only Tyr(P) residue, but also the Ser(P) and Thr(P ...
Bryan M Zhao +8 more
doaj +2 more sources
The Tinkerbell (Tink) Mutation Identifies the Dual-Specificity MAPK Phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a Novel Regulator of Organ Size in Arabidopsis. [PDF]
PLoS ONE, 2015 Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants.
Kim L Johnson +8 more
doaj +3 more sources
Mesalazine Regulates DUSP1, DUSP4, and DUSP5 Expression in Colorectal Cancer: In Vitro and Bioinformatic Evidence [PDF]
PharmaceuticsColorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide, with its development closely linked to dysregulation of mitogen-activated protein kinase (MAPK) signaling pathways. Background: Dual-specificity phosphatases
Marcel Madej +5 more
doaj +2 more sources
A conserved non-canonical docking mechanism regulates the binding of dual specificity phosphatases to cell integrity mitogen-activated protein kinases (MAPKs) in budding and fission yeasts. [PDF]
PLoS ONE, 2014 Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs.
Almudena Sacristán-Reviriego +4 more
doaj +2 more sources
DUSP29 does not regulate melanoma–myoblast interactions in a skeletal muscle co-culture model [PDF]
Scientific ReportsSkeletal muscle, despite constituting nearly half of human body mass, is rarely affected by metastatic spread. The biological mechanisms underlying this relative resistance remain poorly understood.
Sercan Ön +5 more
doaj +2 more sources