Results 11 to 20 of about 40,110 (297)

Dual-specificity phosphatases regulate mitogen-activated protein kinase signaling in adipocytes in response to inflammatory stress. [PDF]

Cell Signal, 2019
Ferguson BS, Nam H, Morrison RF.
europepmc   +3 more sources

DUSP12 promotes cell cycle progression and protects cells from ZNF622 mediated apoptosis [PDF]

Cell Death and Disease
Protein phosphatases are critical for regulating cell signaling, cell cycle, and cell fate decisions, and their dysregulation leads to an array of human diseases like cancer.
Mai Abdusamad, Xiao Guo, Ivan Ramirez, Erick F. Velasquez, Whitaker Cohn, Ankur A. Gholkar, Immy A. Ashley, Yennifer Delgado, Mehdi Bouhaddou, Julian P. Whitelegge, Robert Damoiseaux, Jorge Z. Torres   +11 more
doaj   +2 more sources

The progress of research into pseudophosphatases

Frontiers in Public Health, 2022
Pseudophosphatases are a class of phosphatases that mutate at the catalytically active site. They play important parts in many life processes and disorders, e.g., cell apoptosis, stress reaction, tumorigenesis, axon differentiation, Charcot-Marie-Tooth ...
Deqiang Liu, Yiming Zhang, Hui Fang, Jinxiang Yuan, Jinxiang Yuan, Lizhen Ji   +5 more
doaj   +1 more source

Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases. [PDF]

Int J Mol Sci, 2017
Bhore N, Wang BJ, Chen YW, Liao YF.
europepmc   +2 more sources

Interaction between MAPKs and MKPs in hexaploid chrysanthemum illuminates functional paralogue diversification in polyploids

Horticultural Plant Journal, 2023
Mitogen-activated protein kinases (MAPKs, also known as MPKs) regulate diverse cellular and physiological functions, and dual-specificity MAPK phosphatases (MKPs) modulate MAPK signalling through MAPK dephosphorylation and inactivation. Due to lacking of
Qi Yu, Luyao Zhang, Daojin Sun, Yueheng Hu, Peiling Li, Xue Zhang, Lian Ding, Lijie Zhou, Zhiyong Guan, Weimin Fang, Fadi Chen, Aiping Song   +11 more
doaj   +1 more source

Developmental Roles of the Hog1 Protein Phosphatases of the Maize Pathogen Cochliobolus heterostrophus

Journal of Fungi, 2021
Protein phosphorylation cascades are universal in cell signaling. While kinome diversity allows specific phosphorylation events, relatively few phosphatases dephosphorylate key signaling proteins.
Rina Zuchman, Roni Koren, Benjamin A. Horwitz   +2 more
doaj   +1 more source

Phosphorylation Dynamics of JNK Signaling: Effects of Dual-Specificity Phosphatases (DUSPs) on the JNK Pathway. [PDF]

Int J Mol Sci, 2019
Ha J, Kang E, Seo J, Cho S.
europepmc   +2 more sources

Global analysis of serine/threonine and tyrosine protein phosphatase catalytic subunit genes in Neurospora crassa reveals interplay between phosphatases and the p38 mitogen-activated protein kinase. [PDF]

, 2013
Protein phosphatases are integral components of the cellular signaling machinery in eukaryotes, regulating diverse aspects of growth and development. The genome of the filamentous fungus and model organism Neurospora crassa encodes catalytic subunits for
Borkovich, Katherine A, Ghosh, Arit, Park, Gyungsoon, Servin, Jacqueline A   +3 more
core   +2 more sources

Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research

Frontiers in Pharmacology, 2015
The transmembrane protein Ci-VSP from the ascidian Ciona intestinalis was described as first member of a fascinating family of enzymes, the voltage sensitive phosphatases (VSPs). Ci-VSP and its voltage-activated homologs from other species are stimulated
Kirstin eHobiger, Thomas eFriedrich
doaj   +1 more source

Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. [PDF]

, 2016
Estrogen receptor (ER)-negative cancers have a poor prognosis, and few targeted therapies are available for their treatment. Our previous analyses have identified potential kinase targets critical for the growth of ER-negative, progesterone receptor (PR)-
Brown, Powel H, Chang, Jenny, Den Hollander, Petra, Fuqua, Suzanne, Hartman, Zachary C, Hill, Jamal, Hilsenbeck, Susan G, Kent Osborne, C, Mazumdar, Abhijit, Mills, Gordon B, Poage, Graham M, Shepherd, Jonathan, Tsimelzon, Anna, Zhang, Yun   +13 more
core   +2 more sources