Results 41 to 50 of about 40,110 (297)

Arylstibonic acids are potent and isoform-selective inhibitors of Cdc25a and Cdc25b phosphatases

, 2012
Arylstibonates structurally resemble phosphotyrosine side chains in proteins and here we addressed the ability of such compounds to act as inhibitors of a panel of mammalian tyrosine and dual-specificity phosphatases. Two arylstibonates both possessing a
Andersen, Boutros, Burke, Claire Scott, David J. Mann, Doman, Gasparotto, Gillian F. Whyte, Huyer, James Stivers, Jessica Knott, Katherine A. Scott, Kim, Kotoris, Kristjansdottir, Lok Hang Mak, Oscar Ces, Pagliarini, Picha, Rosivatz, Rudiger Woscholski, Rudolph, Schmid, Schmid, Seiple, Tonks, Vintonyak, Whisstock, Yu Ye   +28 more
core   +1 more source

DUSP8 phosphatase: structure, functions, expression regulation and the role in human diseases

Cell & Bioscience, 2019
Dual-specificity phosphatases (DUSPs) are a subset of protein tyrosine phosphatases (PTPs), many of which dephosphorylate the residues of phosphor-serine/threonine and phosphor-tyrosine on mitogen-activated protein kinases (MAPKs), and hence are also ...
Tao Ding, Ya Zhou, Runying Long, Chao Chen, Juanjuan Zhao, Panpan Cui, Mengmeng Guo, Guiyou Liang, Lin Xu   +8 more
doaj   +1 more source

An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. [PDF]

, 2009
To address the biological heterogeneity of lung cancer, we studied 199 lung adenocarcinomas by integrating genome-wide data on copy number alterations and gene expression with full annotation for major known somatic mutations in this cancer.
Brennan, C, Broderick, S, Chitale, D, Gerald, W, Golas, B, Gong, Y, Ladanyi, M, Major, J, Motoi, N, Pao, W, Reinersman, J, Rusch, V, Sander, C, Seshan, V, Somwar, R, Szoke, J, Taylor, Barry, Wang, L, Zakowski, M   +18 more
core   +2 more sources

DUSPs, to MAP kinases and beyond

Cell & Bioscience, 2012
Phosphatases are important regulators of intracellular signaling events, and their functions have been implicated in many biological processes. Dual-specificity phosphatases (DUSPs), whose family currently contains 25 members, are phosphatases that can ...
Huang Ching-Yu, Tan Tse-Hua
doaj   +1 more source

Long-time treatment by low-dose N-acetyl-L-cysteine enhances proinflammatory cytokine expressions in LPS-stimulated macrophages. [PDF]

PLoS ONE, 2014
N-acetyl-L-cysteine is known to act as a reactive oxygen species scavenger and used in clinical applications. Previous reports have shown that high-dose N-acetyl-L-cysteine treatment inhibits the expression of proinflammatory cytokines in activated ...
Tomokazu Ohnishi, Kenjiro Bandow, Kyoko Kakimoto, Joji Kusuyama, Tetsuya Matsuguchi   +4 more
doaj   +1 more source

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [PDF]

, 2012
Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes.
Cox, Sarah, Jean, Steve, Kiger, Amy, Robinson, Fred L, Schmidt, Eric J   +4 more
core   +1 more source

Nanobody based dual specific CARs [PDF]

, 2018
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B cell leukemias and lymphomas.
Abken, Hinrich, Bonte, Sarah, De Munter, Stijn, Goetgeluk, Glenn, Ingels, Joline, Kerre, Tessa, Pille, Melissa, Vandekerckhove, Bart, Weening, Karin   +8 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Two homologous putative protein tyrosine phosphatases, OsPFA-DSP2 and AtPFA-DSP4, negatively regulate the pathogen response in transgenic plants. [PDF]

PLoS ONE, 2012
Protein phosphatases, together with protein kinases, regulate protein phosphorylation and dephosphorylation, and play critical roles in plant growth and biotic stress responses.
Hanjie He, Jianbin Su, Shengying Shu, Yang Zhang, Ying Ao, Bing Liu, Dongru Feng, Jinfa Wang, Hongbin Wang   +8 more
doaj   +1 more source

Tyrosine-specific MAPK phosphatases and the control of ERK signaling in PC12 cells [PDF]

, 2006
Contains fulltext : 51121.pdf ( ) (Open ...
Noordman, Y.E., Jansen, P.A.M., Hendriks, W.J.A.J.   +2 more
core   +1 more source